ABSTRACT
BACKGROUND: Skin aging is characterized by dehydration and degradation of the structural components in the dermis. It has been demonstrated that hesperetin possesses collagen synthesis and antioxidant properties and sodium cyclic lysophosphatidic acid (NcPA) increases skin moisture through upregulating the synthesis of hyaluronic acid. AIMS: To evaluate the efficacy and safety of a serum containing hesperetin 0.1% and NcPA 0.1% for photoaged skin. PATIENTS/METHODS: The trial consisted of a 12-week topical application of the test product twice daily. A total of 35 female subjects were enrolled. The primary outcome was the change of skin hydration and elasticity, which were determined by Corneometer and Cutometer measurements. Skin biopsy for histological evaluations and subject's self-assessment were conducted. RESULTS: At week 12, a significant improvement of stratum corneum hydration (p = 0.015) and skin elasticity (p < 0.001) was detected comparing to baseline. The skin biopsy showed significantly improved scores of hyaluronic acid levels (p = 0.034) and elastic fiber structure (p = 0.023). Moreover, the test product resulted in a significant subject-reported overall satisfaction rate 94.3% after 12-week application (p = 0.005). CONCLUSION: Skin care product containing hesperetin and NcPA showed significant antiaging effects on skin hydration and elasticity.
