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5.
Nursing ; 30(3): 30, 2000 Mar.
Article in English | MEDLINE | ID: mdl-11000811
6.
Nursing ; 30(7): 76, 2000 Jul.
Article in English | MEDLINE | ID: mdl-10983107
10.
Nursing ; 29(4): 17, 1999 Apr.
Article in English | MEDLINE | ID: mdl-10578837
11.
Nurs Manage ; 30(6): 44-9; quiz 50, 1999 Jun.
Article in English | MEDLINE | ID: mdl-10562064
12.
16.
19.
Article in English | MEDLINE | ID: mdl-7712235

ABSTRACT

Periodic quantitative HIV-1 plasma cultures were performed on 28 seropositive individuals who had CD4 cells < or = 300/mm3 and who were enrolled in three clinical trials testing the efficacy of didanosine versus zidovudine monotherapy. Most plasma cultures were negative or of low titer (1-100 tissue culture infective dose/ml of plasma), but there were 14 instances of high-titered plasma viremia (> or = 1,000 tissue culture infective dose/ml of plasma) seen in 11 individuals. These peaks in plasma culture titers were significantly associated either with rapidly decreasing CD4 cell numbers or with CD4 cells already < 50/mm3. In addition, patients who experienced these episodes of high-titered plasma viremia were more apt to have clinical complaints of fever, rash, flu-like illness, and/or opportunistic infection and also the syncytium-inducing HIV-1 phenotype and progression of disease.


Subject(s)
HIV Seropositivity/virology , HIV-1/isolation & purification , Plasma/virology , Viremia/virology , AIDS-Related Opportunistic Infections/complications , Adult , CD4 Lymphocyte Count , Cohort Studies , Disease Progression , Erythema , Female , Fever , Giant Cells/virology , HIV Seropositivity/complications , HIV Seropositivity/immunology , HIV-1/physiology , Humans , Male , Middle Aged , Retrospective Studies , Viremia/complications , Viremia/immunology
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