Back to basics: ankle reflex in the evaluation of peripheral neuropathy in type 2 diabetes mellitus.

BACKGROUND: Ankle reflex is a simple screening tool frequently used in the detection of peripheral neuropathy. AIM: The purpose of this study is to assess the performance characteristics of ankle reflex in detecting diabetic peripheral neuropathy (DPN) by evaluating the sensitivity, specificity and the predictive ability of the ankle reflex, a component of Neuropathy Disability Score (NDS) with reference to Nerve Conduction Studies (NCS). METHODS: A total of 151 patients with type 2 diabetes were assessed (47 males, 104 females). Grading of neuropathy was done using Neuropathy Symptom Score (NSS), NDS and NCS. Patients were divided into two groups, those with abnormal NCS (Group 1) and those with normal NCS (Group 2). Demographic characteristics, biochemistry, NSS and NDS were assessed between the two groups. Taking NCS as the gold standard, sensitivity, specificity and predictive ability of the ankle reflex were calculated and compared with other tests included in NDS, namely vibration sense, superficial pain and temperature sensation. RESULTS: There were 59 (39.1%) patients in Group 1 and 92 (60.9%) in Group 2. NSS and NDS demonstrated strong positive association with NCS. Taking NCS as the gold standard, ankle reflex yielded the highest sensitivity and specificity (91.5 and 67.4%, respectively), closely followed by that of vibration sense. CONCLUSION: Ankle reflex is a powerful screening tool with high sensitivity and negative predictive value, but a combination of ankle reflex and vibration sense has superior sensitivity and specificity compared with either of them done alone for the detection of DPN in clinical settings.

Prevalence of angiotensin-converting enzyme gene insertion-deletion polymorphism in patients with primary knee osteoarthritis.

OBJECTIVE: Angiotensin converting enzyme (ACE) plays an important role in a number of inflammatory and immune related disorders. This study was undertaken to investigate an association between Angiotensin converting enzyme (ACE) gene insertion- deletion (I/D) polymorphism and primary knee osteoarthritis (OA) in Kuwait and to explore a correlation between clinical subgroups of OA and ACE I/D polymorphism genotypes. PATIENTS AND METHODS: The prevalence of ACE gene I/D polymorphism was determined in 115 patients with primary knee OA and 111 ethnically matched healthy controls by using polymerase chain reaction (PCR) of the genomic DNA. The association of ACE gene I/D polymorphism genotypes was also studied with age of disease onset, function and radiological grading. RESULTS: No significant difference was detected in the frequency of ACE gene I/D polymorphism genotypes and alleles between knee OA patients and the controls. The frequency of ACE gene polymorphism genotypes was also studied in subgroups on the basis of clinical parameters of age of onset of disease, function and radiological grading and no significant difference was detected between subgroups of OA patients and the controls. This is in sharp contrast to a previous report from Korea in which a significant association has been reported between ACE gene polymorphism and knee OA. CONCLUSION: This study did not find an association between ACE gene I/D polymorphism genotypes in Kuwaiti patients with primary knee osteoarthritis and the onset or severity of the disease, which is very different from Korean knee OA patients in which an association has been reported.

Effect of gender on orthodromic sensory nerve action potential amplitude.

OBJECTIVE: Studies in the literature have demonstrated a gender effect on sensory nerve action potential (SNAP) amplitude for the median and ulnar nerves by use of the antidromic method of recording. The objective of this study was to determine if performing orthodromic sensory nerve stimulation eliminates the gender bias by removing the finger circumference as a variable. METHODS: Fifty-five healthy subjects participated in the study. The mean age of the subjects was 37.8 +/- 5.9 yr and 35.3 +/- 5.9 yr for men and women, respectively. Orthodromic sensory nerve conduction studies were performed for the median and ulnar nerves measuring the SNAP amplitude by use of standard electrophysiologic technique. RESULTS: The mean finger circumference of the third digit was 6.5 +/- 0.58 cm for men and 5.9 +/- 0.47 cm for women, and for the fifth digit, it was 5.6 +/- 0.41 cm for men and 5.3 +/- 0.37 cm for women. The median SNAP amplitude and their percentiles of 2.5 and 97.5 for the median nerve were 30.0 microV for men and 28.0 microV for women. For the ulnar nerve, they were 16.5 microV for men and 16.0 microV for women. CONCLUSION: The study confirmed that orthodromic sensory nerve stimulation did not have any significant effect on SNAP amplitude between men and women.

Rheumatic complications of alcohol abuse.

The purpose of this report is to review rheumatic complications associated with alcoholism. Data were collected by an English-language literature search using MEDLINE (1966 to December 1991) and references from identified articles. Studies in humans, including case reports of joint disease and allied disorders associated with alcoholism, were reviewed. According to the data identified, alcoholism is associated with many rheumatic problems, including neuropathic arthropathy, hyperuricemia with gouty arthritis, septic arthritis, and joint hypermobility. Osteoporosis, osteonecrosis, and myopathy also are common. Several other rare musculoskeletal complication have been described. Early recognition of these problems is important for management. Further studies are needed to examine the effect of alcohol on connective tissue components in joints.