ABSTRACT
The contribution made by adjuvant hormone therapy in the development of primary multiple endometrial adenocarcinoma (EA) in patients with breast tumors (BT) is not quite clear. The study was based on the data on 5,790 cases of BT treated at our Clinic and 4,447 females screened for hormone-dependent neoplasms. Patients with BT were found to be at high cumulative risk for endometrial carcinogenesis caused by general factors of risk and pathogenesis. The risk was particularly high in BT (stage 1) within 12 months after treatment. There was no correlation between tamoxifen treatment and significant increase in EA frequency. Promotion of tumor proliferation by tamoxifen was identified in endometrial tissue in 62 patients with BT. This may facilitate clinical manifestations of another latent EA in such patients. Dynamic surveillance of the endometrium and ovary should include ultrasonography of pelvic organs and cytologic examination (smears) of the ecto- and endocervix and endometrial aspiration biopsy.
Subject(s)
Antineoplastic Agents, Hormonal/adverse effects , Breast Neoplasms/drug therapy , Endometrial Neoplasms/chemically induced , Estrogen Antagonists/adverse effects , Neoplasms, Hormone-Dependent/drug therapy , Neoplasms, Multiple Primary/chemically induced , Tamoxifen/adverse effects , Antineoplastic Agents, Hormonal/therapeutic use , Estrogen Antagonists/therapeutic use , Female , Humans , Risk , Risk Factors , Tamoxifen/therapeutic use , Treatment OutcomeABSTRACT
The data on the cytological diagnosis of breast cancer in 4.410 patients tuated at the Clinic of the Institute in 1993-1996 are presented. There was histological evidence on 1,479 patients. The sensitivity of cytological examination was 97.2, specificity--92.4, predictive value of positive test--97 and that of negative test--93%. Correlations between cytological evidence, histological pattern, stage and size of tumor are discussed.
Subject(s)
Breast Neoplasms/pathology , Adolescent , Adult , Aged , Aged, 80 and over , Biopsy, Needle , Breast Diseases/pathology , Breast Neoplasms/surgery , Child , Cytodiagnosis , Diagnosis, Differential , Female , Humans , Middle Aged , Neoplasm Staging , Sensitivity and SpecificityABSTRACT
Male and female SHR mice were injected, subcutaneously, 1 mg of 5-bromo-2'-deoxyuridine (BrdUrd) or 0.05 ml of distilled water on days 1, 3 and 7 after birth and painted with 6.15 mkg of TPA dissolved in 0.1 ml of acetone, or acetone alone, twice a week, for 24 weeks, starting at the age of 15 weeks. The animals were followed up for 20 weeks after stopping TPA painting. Skin tumors emerged in TPA-treated animals only. TPA painting was followed by skin papilloma development in 20.9% of males and 36.6% females injected distilled water neonatally, tumors regressing in 88.4% of males and 85.4% of females by the end of the experiment. With combined treatments with BrdUrd and TPA, skin papilloma incidence was 56.5% in males and 52.6% in females, tumors persisting in 52.2% and 39.6%, respectively, until the end of the experiment.
Subject(s)
Bromodeoxyuridine/toxicity , Carcinogens/toxicity , Neoplasms, Experimental/chemically induced , Papilloma/chemically induced , Skin Neoplasms/chemically induced , Tetradecanoylphorbol Acetate/toxicity , Animals , Female , Male , Mice , Mice, HairlessABSTRACT
Female rats at the age of 1, 3, and 14-16 months ("young", "adult" and "old" groups respectively) were bilaterally ovariectomized and one of the removed ovaries was autoimplanted into the spleen. The total intrasplenic ovarian tumour incidence was equal in the rats subjected to the operation at 3 and 14-16 months (77.4% and 80.6% respectively) and tumours developed more frequently in rats exposed to surgery at the age of 1 month (94.5%), P < 0.05. The incidence of Sertoli and Leydig cell tumours was increased and their latency was decreased in the old group in comparison to the adult one. In rats exposed to the operation at the age of 3 months, granulosotheca cell tumours developed more frequently than other tumour types, and in the young group thecomas were discovered more often than in both older groups. Dysgerminomas and luteomas were discovered only in intrasplenic grafts of rats of the young group. It is supposed that the differences in structure and proliferative activity of various ovarian tissues between young, adult and old rats at the moment of intrasplenic transplantation, as well as the differences in their response to gonadotropic stimulation play a significant role in the development of ovarian tumours of varied histogenesis in the intrasplenic ovarian grafts.
