Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Antimicrob Agents Chemother ; 30(2): 270-3, 1986 Aug.
Article in English | MEDLINE | ID: mdl-3532945

ABSTRACT

A mouse model of cerebral nocardiosis was used to determine relative antibiotic efficacy by reducing bacterial colony counts per gram of brain tissue. The antimicrobial agents employed were demonstrated in vitro to be inhibitory to most strains of Nocardia asteroides at very low concentrations. The agents used in this study were imipenem-cilastatin, amikacin, trimethoprim-sulfamethoxazole, and minocycline. Antibiotics were administered every 4 h for 72 h before animal sacrifice. Bacterial colony counts were assayed at various time points before the completion of therapy. Imipenem-cilastatin and amikacin were the most effective agents tested. Trimethoprim-sulfamethoxazole was less effective than imipenem and amikacin but more effective than minocycline. Minocycline did not eradicate intracerebral organisms and was similar to saline (control) in its effects.


Subject(s)
Amikacin/therapeutic use , Brain Diseases/drug therapy , Minocycline/therapeutic use , Nocardia Infections/drug therapy , Sulfamethoxazole/therapeutic use , Tetracyclines/therapeutic use , Thienamycins/therapeutic use , Trimethoprim/therapeutic use , Amikacin/metabolism , Amikacin/pharmacology , Animals , Drug Combinations/metabolism , Drug Combinations/pharmacology , Drug Combinations/therapeutic use , Female , Imipenem , Kinetics , Mice , Minocycline/metabolism , Minocycline/pharmacology , Nocardia asteroides/drug effects , Sulfamethoxazole/metabolism , Sulfamethoxazole/pharmacology , Thienamycins/metabolism , Thienamycins/pharmacology , Trimethoprim/metabolism , Trimethoprim/pharmacology , Trimethoprim, Sulfamethoxazole Drug Combination
SELECTION OF CITATIONS
SEARCH DETAIL
...