ABSTRACT
Was examined 92 patients with congestive heart failure III-IV FC with fraction of emission left ventricle < 45% against coronary artery disease. Patients of control group received basic therapy (according to recommendations of the Ukrainian society of cardiology), the 1 group--in addition received a preparation of Vazonat within 15 days intravenously in a dose of 1000 mg a day further are out-patient within 1 month on 250 mg 3 times per os; the 2 group--under the same scheme a preparation of Vazonat and a day tranquilizer of Adapto in a dose of 500 mg twice a day throughout all term of supervision. It is established that addition of Vazonat to basic treatment leads to additional effect concerning improvement of indicators cardio-hemodynamic, to improvement congestive functions. Joint appointment of preparations of Vazonat and Adaptol against basic treatment leads to more expressed improvement congestive functions, to progressive reduction of degree of trouble, depression.
Subject(s)
Anti-Anxiety Agents/therapeutic use , Biureas/therapeutic use , Cardiovascular Agents/therapeutic use , Heart Failure/drug therapy , Methylhydrazines/therapeutic use , Psychophysiologic Disorders/drug therapy , Aged , Anti-Anxiety Agents/administration & dosage , Anti-Anxiety Agents/adverse effects , Biureas/administration & dosage , Biureas/adverse effects , Cardiovascular Agents/administration & dosage , Cardiovascular Agents/adverse effects , Cognition/drug effects , Drug Therapy, Combination , Echocardiography , Exercise Test , Heart Failure/pathology , Heart Failure/physiopathology , Heart Failure/psychology , Hemodynamics/drug effects , Humans , Methylhydrazines/administration & dosage , Methylhydrazines/adverse effects , Middle Aged , Myocardial Contraction/drug effects , Myocardium/pathology , Neuropsychological Tests , Psychophysiologic Disorders/physiopathology , Psychophysiologic Disorders/psychology , Severity of Illness Index , Treatment OutcomeABSTRACT
A study of the content of myoglobin in the blood serum in 112 patients suffering of acute myocardial infarction showed the relationship between the reduction of this index and the kind of employed therapy (alpha-tocopherol, cytochrom-C, pyracetam). It was established inclusion of alpha-tocopherol in the treatment produced a most pronounced effect on normalization of the increased content of myoglobin.
Subject(s)
Antioxidants/therapeutic use , Hypoxia/drug therapy , Myocardial Infarction/drug therapy , Myoglobin/blood , Aged , Drug Therapy, Combination , Female , Humans , Hypoxia/blood , Male , Middle Aged , Myocardial Infarction/blood , Myocardial Infarction/complicationsABSTRACT
Sixty-eight patients with acute macrofocal myocardial infarction were subdivided in two groups depending on the kind of treatment: routine (nitrates, beta-blocking agents, calcium antagonists) and cytochrom-C. It was found that cytochrom-C produced a positive effect on the indices of myoglobin and cardiac fractions of lactatedehydrogenase-1 and lactatedehydrogenase-2. It is shown that inclusion of cytochrom-C during the first hours of treatment of patients with macrofocal myocardial infarction resulted in an improvement of tissue breathing and amelioration of the peri-infarction zone state.
Subject(s)
Cytochrome c Group/therapeutic use , Myocardial Infarction/drug therapy , Aged , Drug Evaluation , Drug Therapy, Combination , Female , Humans , Isoenzymes , L-Lactate Dehydrogenase/blood , Male , Middle Aged , Myocardial Infarction/blood , Myoglobin/bloodABSTRACT
Observation of groups of patients receiving traditional treatment and alpha-tocopherol indicates that inclusion of this agent in the treatment of patients suffering of myocardial infarction produced a favourable effect on normalization of the reduced stroke volume of the heart and increased peripheral resistance almost in the middle of the acute and beginning of the subacute periods.