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Exp Clin Transplant ; 21(3): 279-285, 2023 03.
Article in English | MEDLINE | ID: mdl-36987804

ABSTRACT

Hematopoietic stem cell transplant is potentially curative for relapsed/refractory leukemia. However, neurotoxicity is common and has been reported in 11% to 59% of children following hematopoietic stem cell transplant. Most pediatric studies of the neurological effects of hematopoietic stem cell transplant have focused on acute neurotoxicity. Limited information is available for long-term neurotoxicity, particularly those cases that are severe and permanent and caused by conditioning chemotherapy. Here, we report 2 cases of relapsed acute lymphoblastic leukemia that achieved long-term remission by haploidentical hematopoietic stem cell transplant but remained complicated with severe and persistent fludarabine-induced neurotoxicity.


Subject(s)
Hematopoietic Stem Cell Transplantation , Precursor Cell Lymphoblastic Leukemia-Lymphoma , Transplants , Humans , Child , Hematopoietic Stem Cell Transplantation/adverse effects , Vidarabine/adverse effects , Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy , Transplantation Conditioning
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