1.
Drug Intell Clin Pharm
; 20(10): 792-5, 1986 Oct.
Article
in English
| MEDLINE
| ID: mdl-3769772
ABSTRACT
Previous research has suggested that concurrent administration of antacid and cimetidine results in lower than expected plasma levels of cimetidine. Because these studies were all of single-dose design, this study was undertaken to determine the nature of the interaction after repeated administration of both drugs. There was no statistically significant difference demonstrated for any of the pharmacokinetic parameters evaluated in the study. Based on these findings, the previous recommendation that administration of antacid and cimetidine be separated in time may not be necessary.
Subject(s)
Antacids/administration & dosage , Cimetidine/blood , Adult , Biological Availability , Cimetidine/administration & dosage , Drug Administration Schedule , Drug Interactions , Humans , Kinetics , Male , Random Allocation
2.
Am Pharm
; NS25(2): 30-4, 1985 Feb.
Article
in English
| MEDLINE
| ID: mdl-3976490