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Chem Commun (Camb)
; 58(68): 9532-9535, 2022 Aug 23.
Article
in English
| MEDLINE
| ID: mdl-35924915
ABSTRACT
A series of site-diversified, fully functionalized diazirine probes are constructed based on a scaffold shared by several marketed EGFR-targeted drugs. The integrated analysis of protein targets of the site-diversified probe toolkit not only unveils more complete target space and helps suggest false positive targets, but also reveals dynamic events of multi-domain target-ligand interaction.