A screening method based on analytic hierarchy process for closed-loop DBS strategies of Parkinson's disease.

BACKGROUND: Closed-loop deep brain stimulation (DBS) is a research hotspot in the treatment of Parkinson's disease. However, a variety of stimulation strategies will increase the selection time and cost in animal experiments and clinical studies. Moreover, the stimulation effect is little difference between similar strategies, so the selection process will be redundant. OBJECTIVE: The objective was to propose a comprehensive evaluation model based on analytic hierarchy process (AHP) to select the best one among similar strategies. METHODS: Two similar strategies, namely, threshold stimulation (CDBS) and threshold stimulus after EMD feature extraction (EDBS), were used for analysis and screening. The values of Similar to Unified Parkinson's Disease Rating Scale estimates (SUE), ß power and energy consumption were calculated and analysed. The stimulation threshold with the best improvement effect was selected. The weights of the indices were allocated by AHP. Finally, the weights and index values were combined, and the comprehensive scores of the two strategies were calculated using the evaluation model. RESULTS: The optimal stimulation threshold for CDBS was 52% and for EDBS was 62%. The weights of the indices were 0.45, 0.45 and 0.1, respectively. According to comprehensive scores, different from the situation where either EDBS or CDBS can be called optimal stimulation strategies. But under the same threshold stimulation, the EDBS was better than the CDBS under the optimal level. CONCLUSION: The evaluation model based on AHP under the optimal stimulation conditions satisfied the screening conditions between the two strategies.

Transparent and broadband absorption-diffusion-integrated low-scattering metamaterial by standing-up lattice.

In this paper, a transparent absorption-diffusion-integrated metamaterial (ADMM) based on standing-up lattice structure is proposed which takes full advantage of electromagnetic absorption and destructive interference simultaneously for the suppression of broadband backward scattering within a wide angular domain, especially for the lower-frequency scattering. The proposed ADMM is constituted by two kinds of rhombic and squared ITO lattices arranged in a pseudorandom distribution and then backed with ITO film. Calculation, simulation, and experimental measurement show that the proposed ADMM can achieve low scattering with normalized reflection less than 0.1 in the frequency band of 6.1-21.0GHz. In addition, owing to the standing-up lattice structure, the averaged optical transmittance of our ADMM reaches the optimal value of around 82.1% in the visible wavelength range of 380-780nm, promising an excellent optical transparency. The proposed comprehensive scheme provides an effective way to achieve broadband scattering suppression and high compatibility with optical transparency, enabling a wide range of applications in the window glass of stealth armament, electromagnetic compatibility facility and photovoltaic solar device.