ABSTRACT
OBJECTIVE: To evaluate the treatment of primary pulmonary NK/T cell lymphoma. METHOD: A case report and review of the literature. The tissue material was obtained by transbronchial biopsy, and the diagnosis was confirmed by pathology. He received five cycles of chemotherapy with L-asparaginase-based regimen. RESULT: He remained complete remission for 2 years following the initial diagnosis. CONCLUSION: Primary pulmonary NK/T cell lymphoma is an aggressive disease. It is usually associated with poor outcome in the literature. L-asparaginase based regimen was effective for our newly diagnosed patient.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Lung Neoplasms/drug therapy , Lymphoma, Extranodal NK-T-Cell/drug therapy , Adult , Aged , Asparaginase/administration & dosage , Female , Humans , Lung Neoplasms/diagnostic imaging , Lymphoma, Extranodal NK-T-Cell/diagnostic imaging , Male , Treatment Outcome , Young AdultABSTRACT
To analyze the clinical characteristics, treatment of extranodal NK/T-cell lymphoma, nasal type, the term "nasal type" describes in the nasal cavity and also in the extranasal sites. There were 82 patients with nasal NK/T lymphoma (group 1) and 11 patients with extranasal NK/T lymphoma (group 2). In group 1, 4 patients gave up treatment. Five patients received radiotherapy (RT) alone. Fifty-seven patients were treated with combination of chemotherapy and RT. Sixteen patients received chemotherapy alone. Most patients (82.9%) had stage I/II disease and a high frequency (about one-third) of B symptoms. The CR rate was 53.8%. The OS rate was 62.8% (49/78 cases). Three patients died in relation to L-asparaginase. Three patients with late relapses occurred at 10 and 17 years from CR, respectively. In group 2, except that one patient received chemoradiotherapy, 10 patients received chemotherapy. Seven patients died. The OS rate was 36.4%. Our study suggested that nasal and extranasal variants of extranodal NK/T lymphoma, nasal type represented different clinical behavior and prognosis. For comparison, extranasal NK/T lymphoma is more aggressive and higher mortality than nasal NK/T lymphoma.
Subject(s)
Lymphoma, Extranodal NK-T-Cell/pathology , Lymphoma, Extranodal NK-T-Cell/therapy , Nose Neoplasms/pathology , Nose Neoplasms/therapy , Adolescent , Adult , Aged , Female , Humans , Lymphoma, Extranodal NK-T-Cell/mortality , Male , Middle Aged , Nose Neoplasms/mortality , Survival Rate , Young AdultABSTRACT
The objective is to investigate the association between pathological type and clinical features, response to treatment and prognosis of primary gastrointestinal Non-Hodgkin's lymphoma (PGINHL). The clinicopathologic features, response to treatment and survival of 124 patients with PGINHL, were investigated retrospectively. Ninety-one patients were treated with surgery, most of which included combined therapy, while 32 patients received chemotherapy alone. Survival analysis was performed by Kaplan-Meier and Cox regression method. The most common immunophenotype was B-cell subtype. In 115 (92.7%) patients of B-cell lymphoma, mucosa-associated lymphoid tissue lymphoma (MALToma) and diffuse large B-cell lymphoma (DLBCL) were 55 and 50 patients, respectively. The patients of two pathological types had different clinical features including stage, B symptoms, sites of tumor, distant involvement, International Prognosis Index Score, size of tumor, and response to treatment. Both overall survival curve and multiple Cox regression analysis indicated that pathological type was statistically significant. The pathological subtype of PGINHL was an important prognostic factor. The patients with MALToma appear to have more favorable prognosis than those with DLBCL.
