Crystal structure of 1-ethyl-5-iodo-indolin-2-one.

In the title indolinone derivative, C10H10INO, all the non-H atoms, except the terminal methyl C atom, are almost coplanar. The mol-ecules are arranged into columns extending along the a-axis direction and inter-act with the mol-ecules in adjacent columns via C-H⋯O hydrogen bonds [H⋯O distance = 2.57 (3) Å] and I⋯I short contacts of 3.8986 (3) Å. A one-dimensional zigzag iodine chain along the a axis is apparent between two neighbouring columns.

1-Ethyl-5-iodo-indoline-2,3-dione.

There are two independent mol-ecules in the asymmetric unit of the title compound, C10H8INO2, which differ in the degree of planarity. The iodo-indoline-2,3-dione skeleton of mol-ecule 1 is essentially planar [mean deviation = 0.003 (2) Šfor the nine non-H atoms of the indoline core, with a maximum deviation of 0.033 (1) Šfor the I atom]. The I atom and O atom in the 3-position of mol-ecule 2 deviate by 0.195 (1) and 0.120 (2) Å, respectively, from the least-squares plane through the nine non-H atoms of the indoline core. Mol-ecules 1 and 2 are roughly coplanar, the mean planes through their cores making a dihedral angle of 6.84 (1)°. This coplanarity results in a layer-like structure parallel to (6,11,17) in the crystal, the distance between adjacent least-squares planes through the cores of mol-ecules 1 and 2 being 3.37 (1) Å. In such a layer, mol-ecules 1 and 2 are linked by C-H⋯O hydrogen bonds, forming chains along [11-1]. The chains are further coupled to construct a kind of double-chain structure via I⋯O inter-actions [3.270 (2) Å].

Switching high two-photon efficiency: from 3,8,13-substituted triindole derivatives to their 2,7,12-isomers.

Bridging the triindole core and triarylboryl acceptor by an ethenylene linker at the 3,8,13- or 2,7,12-position, the resultant 3-BET and 2-BET show two-photon absorption (TPA) cross sections of δ = 2100 and 2500 GM (at 810 nm by femtosecond pulses in THF), respectively. The TPA enhancement of the 2,7,12-isomers is also found when comparing 3-BYT and 2-BYT (δ = 870 and 1900 GM) and 3-NET and 2-NET (36 and 400 GM).

[Psychological stress status in patients with acute coronary syndrome and stable angina pectoris].

OBJECTIVE: To observe the psychological stress status in patients with acute coronary syndrome (ACS) and stable angina pectoris (SA). METHODS: The intensity of social psychological stress and the serum levels of IL-6, CRP and ICAM-1 were determined in patients with ACS (n = 67) and SA (n = 33). RESULTS: (1) The percentage of patients with psychological stress was significantly higher in ACS than that in SA group (78.8% vs. 21.2%, P < 0.01). (2) The serum levels of CRP [(14.82 +/- 5.07) g/L vs. (8.78 +/- 4.34) g/L], IL-6 [(101.7 +/- 22.2) ng/L vs. (71.1 +/- 23.5) ng/L] and sICAM-1 [(1.41 +/- 0.47) mg/L vs. (0.82 +/- 0.37) mg/L] were significantly higher in psychological stress group than those in non-psychological stress group (all P < 0.05). Serum CRP [(18.91 +/- 3.12) g/L vs. (6.20 +/- 2.46) g/L], IL-6 [(114.6 +/- 15.2) ng/L vs. (56.4 +/- 15.8) ng/L] and sICAM-1 [(1.67 +/- 0.39) mg/L vs. (0.63 +/- 0.28) mg/L] levels in ACS group were significantly higher than those in SA group (all P < 0.01). CONCLUSION: Higher psychological stress was associated with higher risk of ACS and increased serum inflammatory cytokines.