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Asian Pac J Cancer Prev ; 13(5): 2415-8, 2012.
Article in English | MEDLINE | ID: mdl-22901231

ABSTRACT

OBJECTIVE: To investigate the efficacy and safety of voriconazole in treating Chinese patients with hematological malignancies and invasive aspergillosis. METHODS: From March 2007 to April 2012, patients with diagnoses confirmed by CT, GM test and/or PCR assays, were recruited into this study. Aspergillosis of all patients were treated with voriconazole 6 mg/kg intravenous infusion (iv) every 12 h for 1 day, followed by 4 mg/kg IV every 12 h for 10-15 days; Then, switch to oral administration that was 200 mg every 12 h for 4-12 weeks. Efficacy and safety were evaluated according to Practice Guideline of Infectious Diseases Society of America. RESULTS: The overall response rate of 38 patients after voriconazole treatment was 81.6%. The median time to pyretolysis was 4.5 days. Treatment related side effects were mild and found in only 15.8% of cases. No treatment related deaths occurred. CONCLUSIONS: Voriconazole can considered to be a safe and effective front-line therapy to treat patients with hematological malignancies and invasive aspergillosis. Alternatively it could be used as a remedial treatment when other antifungal therapies are ineffective.


Subject(s)
Antifungal Agents/therapeutic use , Aspergillosis/drug therapy , Hematologic Neoplasms/drug therapy , Pyrimidines/therapeutic use , Triazoles/therapeutic use , Administration, Oral , Aspergillosis/etiology , Female , Follow-Up Studies , Hematologic Neoplasms/complications , Humans , Male , Middle Aged , Prognosis , Voriconazole
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