[Diagnostic significance of determining gamma-glutamyltranspeptidase and alkaline phosphatase activity in blood serum and bile in viral hepatitis B and in bile duct inflammation]. / Diagnosticheskoe znachenie opredeleniia aktivnosti gamma-glutamil- transpeptidazy i shchelochnoi fosfatazy v syvorotke krovi i zhelchi pri virusnom gepatite B i vospalenii zhelchnykh putei.

Diagnostic importance of gamma-glutamyl transpeptidase and alkaline phosphatase activities estimation in bile was demonstrated during inflammation of biliary ducts and gallbladder. Activation of these enzymes in B-bile in cholecystitis and in B- and C-bile--in cholecystocholangitis enabled to perform topical diagnosis. Correlation between the enzymatic activity in bile and blood allowed to diagnose acute viral hepatitis B and its combination with inflammation of biliary cuts.

[Effect of verapamil, cromoglycate and dimedrol on the survivability of mice in endotoxic shock]. / Vliianie verapamila, khromoglikata i dimedrola na vyzhivaemost' myshei pri éndotoksicheskom shoke.

The trial has been performed on blocking the potentiation of the lethal action of Sh. Sonnei endotoxin isolated using the agents possessing antiaggregation and antimediator properties--verapamil, cromoglycate and diphenhydramine. It was shown that LD50 of endotoxin increased 2-2.5-fold, provided there were 3 drug injection 1, 4 and 9 hours after endotoxin administration. The survival of mice at 100% level of mortality was also increased 2-2.5-fold. With endotoxin administered together with the first drug injection, the drugs were ineffective. In case endotoxin was administered 3 times at a 4-hour interval prophylactic and therapeutic effects of the drugs and their combinations have been observed.

[Effect of histamine and H1-receptor blockaders on bacterial endotoxin-induced thrombocyte aggregation]. / O vliianii gistamina i blokatorov H1-retseptorov na indutsirovannuiu bakterial'nym éndotoksinom agregatsiiu trombotsitov.

Histamine and dimedrol exerted in vitro inhibitory effects on endotoxin-induced platelet aggregation. When administered at high concentrations pyrilamine potentiated aggregating influence of endotoxin. The experimental results indicate difference in effects of dimedrol and pyrilamine falling into the same group of H1-blockers in relation to induced platelet aggregation.

[Comparative pharmacological analysis of the mechanisms of thrombocyte aggregation induced by bacterial toxins and ADP]. / Sravnitel'nyi farmakologicheskii analiz mekhanizmov agregatsii trombotsitov, indutsirovannoi bakterial'nymi toksinami i ADF.

It has been demonstrated in experiments in vitro that exotoxin and endotoxin of Shigella sonnei produce the concentration-dependent rabbit platelet aggregation. Acetylsalicylic acid and theophylline substantially inhibit the ADP-induced aggregation and suppress to a less degree the effects of bacterial toxins. Monoiodine acetate inhibits aggregation induced by ADP and potentiates the aggregating action of toxins.

[Effect of bacterial endotoxin on gastric emptying and on passive absorption of salicylate in the small intestine]. / O vliianii bakterial'nogo éndotoksina na zheludochnuiu évakuatsiiu i passivnoe vsasyvanie salitsilata v tonkoi kishke.

The salicylate content in blood plasma after its administration into the stomach and small intestine during experimental endotoxemia in mice has been measured. In early stages of intoxication gastric evacuation was fairly slow. Histamine increased, while its antagonist pyrilamine significantly reduced the observed disorder. In the last stages of intoxication, passive absorption in the small intestine increased. Administration of histamine, serotonin and ciproheptadine did not produce any essential effect on the salicylate transport across the intestinal wall.

[Effect of dysentery endotoxin on the histamine and serotonin concentration in the mucosa of the small intestine]. / O vliianii dizenteriinogo éndotoksina na soderzhanie gistamina i serotonina v slizistoi obolochke tolstogo kishechnika.

An increase in histamine content and a decrease in serotonin concentration occurred in mucosa of mouse large intestine in dynamics of dysenteric intoxication. The content of serotonin was more dependent on the endotoxin dose and duration of its action of these biogenic amines in normal state was altered under the pathological conditions. The impairments in metabolism of biogenic amines in response to dysenteric intoxication were reduced after administration of tryptophane and pyridoxine suggesting the reversibility of these impairments.

[Serotonin inactivation by tissues of the gastrointestinal tract and liver in the presence of dysenteric poisoning]. / Ob inaktivatsii tkaniami zheludochno-kishechnogo trakta i pecheni serotonina v usloviiakh dizenteriinoi intoksitkatsii.

Intravenous administration of serotonin into healthy rabbits was accompanied by an increase in content of serotonin in blood of vena cava inferior but the level of serotonin in blood of vena portae and vena centralis hepatis was unaltered. Concentration of serotonin was increased in all parts of the venous system studied after administration of serotonin into andogenous histamine was stimulated. Administration of iproniazid, simultaneously with the dysenteric toxin, led to decrease in inactivation not only of serotonin, but also of histamine.