Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Language
Publication year range
1.
J Org Chem ; 84(8): 4735-4747, 2019 04 19.
Article in English | MEDLINE | ID: mdl-30352146

ABSTRACT

A multidisciplinary approach covering synthetic, physical, and analytical chemistry, high-throughput experimentation and experimental design, process engineering, and solid-state chemistry is used to develop a large-scale (kilomole) Suzuki-Miyaura process. Working against clear criteria and targets, a full process investigation and optimization package is described highlighting how and why key decisions are made in the development of large-scale pharmaceutical processes.


Subject(s)
Drug Design , Drug Industry , Pyrazines/chemical synthesis , Triazines/chemical synthesis , High-Throughput Screening Assays , Molecular Structure , Pyrazines/chemistry , Triazines/chemistry
2.
J Forensic Sci ; 55(1): 237-40, 2010 Jan.
Article in English | MEDLINE | ID: mdl-19925587

ABSTRACT

The Food and Drug Administration does not require surgical sutures to be tracked by manufacturer, physician, or patient; thereby, surgical sutures have been of little use to forensic practitioners who are tasked with establishing a positive identification with biological evidence. This study demonstrates the investigative process used to pinpoint suture manufacturers by presenting a case where surgical sutures were a distinctive characteristic that aided in the positive identification of skeletal remains. The suture's manufacturer, construction material and structure, size, and medical use was determined by contacting a local surgical suture and orthopedic implant manufacturer and utilizing publicly available manufacturer websites, which provide catalogs and specific product details. This research was one of many lines of evidence used to establish the positive identification of a 47-year-old male.


Subject(s)
Forensic Anthropology/methods , Sutures , Equipment Design , Humans , Industry , Male , Middle Aged , Scapula/pathology , Scapula/surgery
SELECTION OF CITATIONS
SEARCH DETAIL
...