Bis-Capsules: Cooperative Reversible Encapsulation of Two Molecules in Adjacent Separate Chambers.

Unprecedented communication takes place between guests G that are reversibly encapsulated in adjacent, but physically separate, chambers of a side-to-side bis-capsule (shown schematically). This was shown by neighbor-dependent NMR chemical shifts of the identical or nonidentical guest molecules. Furthermore, no 1:1 host - guest species is formed.