ABSTRACT
We studied the effects of anti-inflammatory substances incorporated in polymeric microparticles made of degradable natural polyhydroxyalkanoate polyesters on experimental skin wounds caused by chemical burns in laboratory animals. Treatment with encapsulated forms of anti-inflammatory substances (applied in gel) accelerated wound healing in comparison with routine therapy (estimated by area of burn wound, wound healing activity, number of acanthotic cells, and number of hair and sebaceous follicles). The results showed the perspectives of usage of developed form of substances (degradable polymeric microparticles) for treatment of skin defects.
Subject(s)
Anti-Inflammatory Agents/administration & dosage , Drug Carriers , Polymers/chemistry , Skin/injuries , Wounds and Injuries/drug therapy , Animals , Mice , Mice, Inbred BALB CABSTRACT
The study investigates electrokinetic potential of microparticles prepared from biodegradable poly-3-hydroxybutyrate depending upon the method of preparation employed and taking into account the size of particles maintained in liquid media. The ζ-potential of microparticles. prepared from emulsion by solvent evaporation method was -20 mV; the ζ-potential of microparticles prepared by spray drying was reduced to -95 mV. The value of ζ-potential was influenced by drug loading into microparticles; the drug-loaded microparticles maintained in balanced phosphate buffer for 30 days had higher physical stability than those without drug loading.
