ABSTRACT
Enterosorption on the carbon material Vaulen was performed in experiments in albino rats with the model of acute pancreatitis. The application of enterosorbents was shown to increase the percentage of survival of the animals, to decrease the activity of pancrease enzymes in the blood, components of the Kallikrein-Kinin system, proteolysis products. The clinical observations support the expediency of using this detoxication method.
Subject(s)
Charcoal , Pancreatitis/therapy , Acute Disease , Adsorption , Amylases/metabolism , Animals , Dogs , Duodenum/metabolism , Intestinal Absorption , Kallikreins/metabolism , Kinins/metabolism , Lipase/metabolism , Pancreatitis/metabolism , Rats , Trypsin/metabolismABSTRACT
Role of lungs in regulation of blood kallikrein-kinin system was studied under conditions of massive hemorrhage in dogs as well as in heavy lung impairments of patients--acute pneumonia, shock of lungs. These stressor effects were shown to correlate with the rate of loss in lung regulating activity towards the blood kallikrein-kinin system.
Subject(s)
Kallikreins/blood , Kinins/blood , Lung Diseases/blood , Lung/blood supply , Acute Disease , Animals , Dogs , Hemorrhage/blood , Humans , Lung/metabolism , Oxygen ConsumptionSubject(s)
Clinical Enzyme Tests , Hemoperfusion , Kallikreins/blood , Kinins/blood , Pneumonia/diagnosis , Respiratory Distress Syndrome/diagnosis , Acute Disease , Animals , Arteries , Dogs , Humans , Kininogens/blood , Pneumonia/therapy , Prekallikrein/blood , Respiratory Distress Syndrome/therapy , VeinsABSTRACT
The authors have demonstrated activation of the Kallikrein-Kinin system in critical states and ways to decrease the level of its components in hemosorption. It was shown in experiments in 15 dogs and 120 rats (in blood loss and endotoxin shock) and in 12 patients (with acute pneumonia, Mendelson syndrome and "shock lung").
