ABSTRACT
A model of hemorrhagic stroke (HS) (intracerebral posttraumatic hematoma) has been used to show that oral Actoinvit (substance S-1) in a daily dose of 500 mg/kg for 7 days causes a steady-state antistroke effect. At the same time the major neurological parameters became lower and the total indices of orientative-trying behavior improved 24 hours just after administration of the drug. Muscle tone, coordination of movements, and memory impairment recovered on days 7-14 after the simulation of HS. The course use of the agent prevented death from HS in 80% of the animals.
Subject(s)
Intracranial Hemorrhages/drug therapy , Morpholines/pharmacology , Stroke/drug therapy , Administration, Oral , Animals , Humans , Intracranial Hemorrhages/pathology , Intracranial Hemorrhages/physiopathology , Male , Rats , Stroke/pathology , Stroke/physiopathology , Time FactorsABSTRACT
Substance S-1 increased energetic potential of skeletal muscles and increased cAMP level in the brain, heart, and liver of male Wistar rats at rest and after forced swimming.
Subject(s)
Blood Proteins/pharmacology , Cyclic AMP/metabolism , Energy Metabolism/drug effects , Stress, Physiological/metabolism , Adenine Nucleotides/metabolism , Animals , Blood Proteins/isolation & purification , Brain/drug effects , Brain/metabolism , Chickens , Heart/drug effects , Liver/drug effects , Liver/metabolism , Male , Muscle, Skeletal/drug effects , Muscle, Skeletal/metabolism , Myocardium/metabolism , Physical Exertion , Rats , Rats, Wistar , Swimming , Tissue DistributionABSTRACT
Intraperitoneal administration of substance S-1 to male Wistar rats with impaired hearing markedly increased hearing acuity. Substance S-1 had no negative effects on hearing in intact animals.
Subject(s)
Blood , Hearing Loss/therapy , Acoustic Stimulation , Animals , Blood Proteins/chemistry , Blood Proteins/therapeutic use , Freeze Drying , Male , Molecular Weight , Rats , Rats, WistarABSTRACT
In vivo experiments on the model of wound healing showed that thrombin and thrombin receptor agonist TRAP-6 stimulated heparin secretion by mast cells in rat subcutaneous fat: the saturation of mast cells with heparin decreased, while degranulation and granulolysis increased. In vitro studies showed that TRAP-6 caused a dose-dependent release of beta-hexosaminidase from peritoneal mast cells. TRAP-6 also induced heparin release from these cells and inhibition of amidase activity of thrombin. Heparin released from mast cells had low anticoagulant activity. These data suggest that activation of mast cells with thrombin is mediated by PAR-1.
