ABSTRACT
In a randomized, double-blind, double-dummy, crossover study consisting of two 1-month periods with a 2-week 'run-in' we compared the effects of a combination of fenoterol with ipratropium bromide (Duovent, Boehringer Ingelheim) and salbutamol administered by standard metered dose inhalers in conventional dosage in young adults with nocturnal asthma. Seventeen patients were studied, all were aged between 19 and 35 years and showed 'morning dip' associated with nocturnal symptoms of cough, wheeze and breathlessness. They recorded morning and evening peak flows and symptoms of nocturnal asthma on diary cards. Over the 10 weeks of the study there was no difference between Duovent and salbutamol in any of the parameters measured.
Subject(s)
Albuterol/therapeutic use , Asthma/drug therapy , Atropine Derivatives/administration & dosage , Fenoterol/administration & dosage , Ipratropium/administration & dosage , Administration, Inhalation , Adult , Albuterol/administration & dosage , Clinical Trials as Topic , Double-Blind Method , Drug Combinations/administration & dosage , Drug Combinations/therapeutic use , Female , Fenoterol/therapeutic use , Humans , Ipratropium/therapeutic use , Male , Random AllocationABSTRACT
A 60-year-old man with seropositive rheumatoid arthritis developed rapidly progressive dyspnoea and bilateral pulmonary infiltrates on short exposure to 50 mg penicillamine daily. He made a satisfactory recovery following cessation of penicillamine therapy and the addition of prednisolone. This case has been reported to the Committee on Safety of Medicines and we would like to emphasize that the possibility of penicillamine-induced lung disease should be recognized, even on a small dose of short duration.
Subject(s)
Arthritis, Rheumatoid/drug therapy , Penicillamine/adverse effects , Pulmonary Fibrosis/chemically induced , Humans , Male , Middle Aged , Penicillamine/therapeutic use , Prednisolone/therapeutic use , Pulmonary Fibrosis/diagnostic imaging , RadiographyABSTRACT
A patient with a phaeochromocytoma associated with hypercalcemia is described. The hypercalcaemia was corrected by removal of the phaeochromocytoma. Parathyroid hormone-like peptide was isolated from the tumour suggesting that ectopic parathyroid hormone production from the phaeochromocytoma was the explanation of the hypercalcaemia.
