Self-rated peri-implant oral symptoms and clinicoradiographic characteristics in Narghile-smokers, cigarette-smokers, and nonsmokers with peri-implantitis.

BACKGROUND: The hypothesis is that self-rated peri-implant oral symptoms (OS) and clinical (plaque index [PI] and probing depth [PD]) and radiographic (crestal bone loss [CBL]) are higher in (cigarette-smokers [CS]) and (waterpipe-users) than (nonsmokers [NS]). The aim was to relate peri-implant self-perceived OS with clinico-radiographic parameters among CS, waterpipe-users, and NS. MATERIALS AND METHODS: This study was performed on self-reported CS, waterpipe-users, and NS with peri-implantitis. A questionnaire was used to record peri-implant self-perceived OS (pain in gums, bleeding gums, bad breath, and loose implant) and demographic data (age, sex, duration of smoking and waterpipe usage, duration of implants in function, duration since diagnosis of peri-implantitis). Clinico-radiographic parameters (CBL, PD, PI, and bleeding on probing [BOP]) were also measured; and compared with the self-perceived OS. Group comparisons were done for perceived OS and clinico-radiographic variables, and significant differences were deemed when P-values were under .05. RESULTS: One hundred male participants (35 CS, 33 waterpipe-users, and 32 NS) with peri-implantitis were included. Pain in gums (P < .05) and bad breath (P < .05) were more frequently perceived by CS and waterpipe-users than NS. There was no significant difference in perceived bleeding gums around the implant or loose implant among all groups. The CBL (P < .01), PI (P < .001), and PD (P < .01) were significantly high in CS and waterpipe-users than NS. NS (P < .05) had significantly higher BOP than waterpipe-users and CS. There was no significant difference in CBL, PI, PD, and BOP among waterpipe-users and CS. CONCLUSION: Tobacco-smokers present with worse peri-implant perceived OS and clinicoradiograhic parameters than nonsmokers with peri-implantitis.

Association of Selected Adipocytokines and Inflammatory Markers on Body Mass Index in Type 2 Diabetes Patients in Saudi Arabia and as Risk Factors to Cardiovascular Disease.

INTRODUCTION: In this prospective study, we establishing the association of obesity in type 2 diabetes patients with various inflammatory markers and adipocytokines, as risk factors for cardiovascular disease (CVD). MATERIALS AND METHODS: In this work, a total of 85 individuals gave concern and were divided into 4 groups based on their body mass indices (BMI). Anthropometrics details were obtained from each individual and different laboratory tests were performed to measure levels of adipocytokines such as adiponectin, leptin and resistin and inflammatory markers such as TNF-α, IL-6 and hsCRP. All the 82 patients with T2D were studied in four groups, A includes obese with BMI >30 kg/m2, B includes overweight with BMI ranging 25 to 30 kg/m2), C includes non-obese with BMI < 25 kg/m2. Group D was control, included non-obese (BMI < 25 kg/m2) and non-diabetic individuals. Result & Discussion: There was an increase in plasma insulin levels in T2D patients, especially with exhibiting high BMI and diabetic conditions in Group A. Adiponectin was higher in the control group which is significant with the value of p<0.05 compared to other three groups. There was negative correlation observed found to be significant, between obesity and adiponectin. Positive correlation was seen among leptin, resistin and inflammatory markers among T2D and control individuals which were significant. T2D groups had an increase in plasma insulin and adiponectin, but decreased leptin, resistin and inflammatory markers compared to control. Overall, T2D patients showed a significant correlation between plasma insulin, adipocytokines and other inflammatory markers clearly designate the impact of metabolic conditions such as obesity on these factors and vice versa. Increased levels of the parameters restrained in the study correlate T2D and obesity to cardiovascular diseases.

Antimicrobial effects of Citrus sinensis peel extracts against dental caries bacteria: An in vitro study.

BACKGROUND: Ethnomedicine is gaining admiration since years but still there is abundant medicinal flora which is unrevealed through research. The study was conducted to assess the in vitro antimicrobial potential and also determine the minimum inhibitory concentration (MIC) of Citrus sinensis peel extracts with a view of searching a novel extract as a remedy for dental caries pathogens. MATERIAL AND METHODS: Aqueous and ethanol (cold and hot) extracts prepared from peel of Citrus sinensis were screened for in vitro antimicrobial activity against Streptococcus mutans and Lactobacillus acidophilus, using agar well diffusion method. The lowest concentration of every extract considered as the minimal inhibitory concentration (MIC) values were determined for both test organisms. One way ANOVA with Post Hoc Bonferroni test was applied for statistical analysis. Confidence level and level of significance were set at 95% and 5% respectively. RESULTS: Dental caries pathogens were inhibited most by hot ethanolic extract of Citrus sinensispeel followed by cold ethanolic extract. Aqueous extracts were effective at very high concentrations. Minimum inhibitory concentration of hot and cold ethanolic extracts of Citrus sinensis peel ranged between 12-15 mg/ml against both the dental caries pathogens. CONCLUSIONS: Citrus sinensispeels extract was found to be effective against dental caries pathogens and contain compounds with therapeutic potential. Nevertheless, clinical trials on the effect of these plants are essential before advocating large-scale therapy. KEY WORDS: Agar well diffusion, antimicrobial activity, dental caries, Streptococcus mutans, Lactobacillus acidophilus.