[The antitryptic activity of the blood in pulmonary tuberculosis patients who smoke tobacco]. / Sostoianie antitripticheskoi aktivnosti krovi bol'nykh tuberkulezom legkikh, kuriashchikh tabak.

The general activity of the antitryptic system of the blood was studied in 60 practically healthy persons and in 65 patients with active tuberculosis. A group of tobacco smokers (5 years, 6-10 years) was singled out. It was established that tobacco smoking and pulmonary tuberculosis was accompanied by activation of the antitryptic system which should be considered as a peculiar defensive reaction of the body to increase of the proteolytic activity of enzymes in the lungs. In persons that have been smoking from 6 to 10 years there was a reduction of the general antitryptic activity which can further the development of dystrophic changes in the pulmonary parenchyma and produce an unfavourable effect on the course of specific inflammation.

[Treatment efficacy in destructive forms of pulmonary tuberculosis in relation to the methods of administering rifadin and isoniazid]. / Effektivnost' lecheniia destruktivnykh form tuberkuleza legkikh v zavisimosti ot sposobov vvedeniia rifadina i izoniazida.

The efficacy was studied of 130 patients with freshly detected destructive forms of pulmonary tuberculosis depending on the method of administration of rifadin and isoniazid. Treatment of pulmonary tuberculosis was realized with rifadin, isoniazid and streptomycin. Three groups of patients were distinguished. In group I rifadin and isoniazide was taken orally, in group II--rifadin was administered orally and intrabronchially, isoniazid--orally. In group III rifadin was orally and intrabronchially, isoniazid--intravenously. The treatment was more effective with combined administration of rifadin and intravenous administration of isoniazid.