[Effect of nerobol on the histophysiology of the islands of Langerhans of intact and castrated female rats]. / Vliianie nerobola na gistofiziologiiu insuliarnogo apparata podzheludochnoi zhelezy intaktnykh i kastrirovannykh krys-samok.

Experiments were conducted on 250 albino female rats, 100 to 120 g in weight. A study was made of the influence of nerobol on the insular apparatus of the pancreas. A 10-day administration of nerobol in a dose of 10 mg/kg stimulated the functional activity of the insular apparatus, facilitated the course of alloxan diabetes, increased the tolerance of the beta-cells of the islets to alloxan both in intact and in castrated female rats.

[Morphofunctional changes in the insular apparatus of the pancreas following hypophysectomy and administration of somatotropic hormone]. / Morfofunktsional'nye izmeneniia insuliarnogo apparata podzheludochnoi zhelezy v usloviiakh gipofizéktomii i vvedeniia somatotropnogo gormona.

Mature white male rats were used to study effects of hypophysectomy and STH on sugar content after fasting and after reiterated glucose loading. Morphological and morphometrical investigation of the pancreatic endocrine tissue were made. Zinc content and distribution in the pancreas, as well as aldehydefuchsinophil granulation in B-cells of the islets of Langergans were studied. Hypophysectomy was stated to increase functional activity of the pancreatic insular apparatus. Injection of STH for 9 days resulted in the stimulation of the cells in the insular apparatus. Prolonged injection of STH (for 20 days) produced exhaustion of the pancreatic insular apparatus.

[Histopathomorphologic changes in the organs and tissues of laboratory animals receiving an artificial diet with a low selenium and vitamin E content]. / Gistopatomorfologicheskie izmeneniia v organakh i tkaniakh laboratornykh zhivotnykh, poluchavshikh iskusstvennyi ratsion s nizkim soderzhaniem selena i vitamina E.

The deficiency of selenium and vitamin "E" is not infrequently noted to occur in agricultural and game-animals. Its development in humans is not ruled out. Experiments set up on mice of the CC57 lineage fed on an artificial ration with a low selenium and vitamin "E" content showed an acute selenium and vitamin "E" deficit apt to call forth profound histopathomorphological changes that become apparent following hematoxylin-eosin staining in the pancreas, liver, heart, kidneys, testes and muscular tissue. Evidence was obtained for the first time that an acute selenium and vitamin "E" deficiency leads up to a drastic fall in the content of zinc, determined by the sulfargentic method, as well as in the insular cells of the pancreas, in the renal parenchyma and in the cells of the spermatogenic epithelium of the testes.