[Approaches to occupational evaluation of allergy danger caused by work conditions]. / Podkhody r gigienicheskoi otsenke allegoopasnosti uslovii truda.

The authors defined major criteria for allergenic danger caused by work conditions. The criteria include sensibilizing activity, intensity of chemical allergen, routes of its intake, combinations and associations with other occupational hazards and, according to hygienic classification of work and to classification of chemical allergens, to importance in causing the allergic diseases, are assessed in points. Using the criteria, considering various associations of allergies and concomitant factors and their correspondence to occurrence and severity of immunologic and allergic disorders, clinical signs of allergies (including occupational), the authors specified integral scale for evaluation of allergenic danger caused by work conditions.

[Occupational regulations of the use of terpene compounds in the air of the workplace]. / Gigienicheskoe reglamentirovanie terpenovykh coedinenii v vozdukhe rabochei zony.

Based on results of 15-years complex study, the authors present toxicological and hygienic characteristics of terpene compounds (with mono- and bicyclic structure) and their compositions. The article deals with toxicodynamics and toxicokinetics of terpenoids, dependence of toxic properties on the chemical structure. The article also touches upon studies of biologic and specific (sensibilizing activity, embryotoxic and gonadotropic, membranotropic) effects of terpenoids. Some aspects concerning hygienic regulation of terpene compounds are also covered.

[An experimental validation of the maximum permissible concentration of a mixture of mono- and bicyclic terpenoid alcohols in water]. / Eksperimental'noe obosnovanie predel'no dopustimoi kontsentratsii smesi mono- i bitsiklicheskikh terpenoidnykh spirtov v vode.

The maximum permissible concentrations (MPC) of Viterol in water were established, which was equal to 0.14 mg/l. Its organoleptic and general sanitary thresholds were determined at the same level.

[Luminescent analysis of peripheral blood lymphocytes in subjects engaged in production hazardous in reference to allergens]. / Liuminestsentnyi analiz limfotsitov perifericheskoi krovi pri obsledovanii liudei, zaniatykh na allergoopasnom proizvodstve.

The authors demonstrate the possibility of using the fluorescent analysis of the peripheral blood lymphocytes for the detection of the specific sensitization of the body to allergens and of immune deficiency. A positive correlation has been revealed between intensified fluorescence (at 640 nm) of blood lymphocytes stained with fluorochrome acridine orange, in vitro stimulated with a specific allergen, and the blood serum antihapten humoral antibodies, as well as deviations of some other laboratory parameters from the norm. High informative value of the fluorescent analysis, use of small quantities of blood recommend this method for screening examinations and formation of groups at risk of developing occupational diseases.

[Allergenic properties of various natural and modified colofonies]. / Allergennye svoistva nekotorykh prirodnykh i modifitsirovannykh kanifolei.

Natural tall colophony and its modification by monoethanolamine are moderate allergens at intracutaneous and epicutaneous ways of sensibilization reproduction. In the conditions of 30-days inhalational exposure in concentrations on the level of Limch modified by monoethanolamine colophony does not cause sensitization; while the modified tall colophony induces a weakly expressed allergic effect in experimental guinea pigs--albinos.

[Biological factors as occupational hazards in agriculture]. / Biologicheskii faktor kak proizvodstvennaia brednost' v sel'skom koziaistve.

The article provides data obtained from both the national and foreign publications on the role of the biological factor in modern agricultural production. An account of the agricultural branches is given in which the role of this factor is most predominant. Particular emphasis is laid on the diversity of its influence on man with resulting allergies, infections and intoxications, and on the necessity of the standardization of most hazardous biological factors.

[Data on the establishment of group MPEL for natural and modified colophony in the workplace air]. / Materialy k obosnovaniiu gruppovoi PDK prirodnykh i modifitsirovannykh kanifolei v vozdukhe rabochei zony.

The results of the toxico-hygienic study of 12 types of rosins are presented. It is established that these compounds are moderately hazardous products with slightly pronounced local irritating and skin resorptive effect accompanied by moderate sensitizing activity. Rosins' cumulative characteristics are not manifested at the lethal level. Lim(ac) are within 110-193 mg/m3 and Lim(ch) within 38.0-42.0 mg/m3. The analyzed types of rosins possess polytropic general toxicity with primary impact on the functional state of liver, kidneys and the nervous system. The above studies have enabled one to recommend group MAC for rosins in the workplace air at the level of 4 mg/m3 and their marking as allergens.