[Influence of formate on free amino acids contents in tissues and organs of rats in vitro and in vivo].

In experiments in vitro and in vivo influence of formiate on free amino acids contents of tissues and organs of rats has been studied. Results of experiments showed a possibility of amino acids formilation in all investigated tissues. This process could be enzymatic. Its effectivness depended on amino acids and formiate concentrations. The most effective processes took place in organs with high metabolic activity.

[Role of formic acid in transformation of acetic and succinic acids in animal tissues]. / Rol' murashynoï kysloty v peretvorenni otstovoï i iantarnoï kyslot u tkanynakh tvaryn.

Acetic and succinate acids KoA acyl derivatives interacting with formate were displayed to produce alpha-ketoacids--pyruvate and alpha-ketoglutarate. These acids also interact with formate and make pyruvic and malate acids, while alpha-ketoglutarate, evidently, tricarboxy acids. Interaction of formate with acetic and succinate acids inspite of occurring out of the tricarbone cycle increases the latter metabolic functions.

[Metabolic changes in the rat liver during emotional stress]. / Narusheniia protsessov obmena veshchestv v pecheni krys pod vliianiem émotsional'nogo stressa.

Emotional stress of rats is accompanied by essential alterations in glycolysis and tricarboxylic acid cycle in the liver. These alterations were observed over a few days after the termination of stressor action. Perhaps it is one of the trigger mechanisms responsible for pathological changes in the organism.

[Change in the intensity of biosynthesis of proteins, lipids and glycogen in animal tissues during long-term administration of morphine]. / Izmenenie intensivnosti biosinteza belkov, lipidov i glikogena v tkaniakh zhivotnykh pri dlitel'nom vvedenii morfina.

The intensity of biosynthesis processes in animal organism has been studied as affected by long-term administration of morphine. It was established that morphine administration to rats for five weeks intensified protein biosynthesis in the brain, kidneys, skeletal muscles: specific radioactivity of blood serum proteins also increased. Incorporation of 2-/14C/glycine label to the brain, cardiac and skeletal muscles increased as affected by morphine: the label incorporation to the liver lipids decreased and that to the kidney and spleen lipids did not change. Specific radioactivity of glycogen multiply increased in the rat liver as affected by morphine.

[Features of metabolic disorders in the liver during morphine poisoning of various duration]. / Osobennosti metabolicheskikh narushenii v pechenii pri morfinnoi intoksikatsii razlichnoi dlitel'nosti.

Administration of morphine into rats at a dose of 30 mg/kg within 6 days led to a decrease in total rate of tRNA aminoacylation in liver tissue. Content of lactate, pyruvate, malate and alpha-ketoglutarate was decreased within 6 days-long course of morphine administration, while content of lactate was only altered after 5 weeks of the intoxication. Adaptation reactions appear to be increased with time in long-term intoxication with morphine.

[Correction with formate of metabolic disorders in alcoholic intoxication]. / Korrektsiia formiiatom metabolicheskikh narushenii pri alkogol'noi intoksikatsii.

Formate was studied for its effect on the content of acetaldehyde, activity of the total aldehyde dehydrogenase, content of substrates of glycolysis and tricarbonic-cycle and pool of free amino acids of rat tissues during alcohol intoxication. The introduction of formate during the acute alcohol intoxication lowers the acetaldehyde content in the blood; the ethanol load being prolonged--it increases the activity of aldehyde dehydrogenase and normalizes the content of pyruvate, glutamate and malate in the liver and glutamate and oxaloacetate in the brain, that evidences for the correction of metabolic disturbances in the organism.

[Carbostimulin-correcting effect on metabolic aspects of diabetes mellitus]. / Korregiruiushchee deistvie karbostimulina na nekotorye storony obmena veshchestv pri sakharnom diabete.

Application of carbostimulin, the preparation stimulating CO2 fixation in tissues, in a complex therapy of diabetes mellitus patients rises the CO2 level, restores the total content of alpha-ketoacids and free amino acids in blood, increases (within the physiological normal limits) the urea content in blood and urine of diabetes mellitus patients.

[Effect of carbostimulin on biosynthetic processes in rabbits with alloxan diabetes]. / Vliianie karvostimulina na biosinteticheskie protsessy u krolikov pri alloksanovom diabete.

In rabbits with alloxane diabetes the intensity of [I-14C] glycine label incorporation into various tissue components is considerably lowered. Stimulation of carboxylation in animals under these conditions intensifies the label incorporation into proteins of the liver, kidneys, spleen as well as into blood serum albumin and globulin. The level of lipids, glycogen in the liver, the total content of proteins in blood serum and their specific radioactivity increase. All this evidences for intensification of biosynthetic processes and for a possibility to normalize the metabolism with diabetes by stimulating the processes of carboxylation.

[Effect of carboxylin and sodium citrate on the content of intermediate products of tricarboxylic cycle, free amino acids and urea in rabbit tissues in alloxan diabetes]. / Vliianie karboksilina i limonnokislogo natriia na soserzhanie promezhutochnykh produktov trikarbonovogo tsikla svobodnykh aminokislot i mocheviny v tkaniakh krolikov pri alloksanovom diabete.

Feeding carboxylin and sodium citrate to rabbits with alloxane diabetes, normalizes the disturbed contents of malate, alpha-ketoglutarate, oxaloacetate, citrate and pyruvate in the blood and liver of these animals restores the total content of alpha-keto-and free amino acids, increases considerably the urea content in the liver.