Laser Test Spots: A Scoping Review.

BACKGROUND: Laser test spots are commonly suggested for the assessment of clinical response and adverse effects, but use by laser operators is not well described. OBJECTIVE: To describe the use of laser test spots in the existing published literature regarding methodology (location, treatment parameters) and objective (clinical efficacy, safety, other). MATERIALS AND METHODS: This scoping review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines and included indexed studies performing test spots in human subjects for dermatologic conditions with clinical reassessment at a subsequent visit. RESULTS: Among 5,261 identified publications, 103 studies with 959 test spots were selected for inclusion. Test spots conducted were mostly on lesional skin (89.3%) assessing both clinical response and adverse effects (76.9%). Most test spots used multiple laser parameters with a single wavelength (48.3%). Fluence was most frequently adjusted either alone (30.1%) or in combination with pulse duration or spot size. Other described test spots examined single set of laser parameters, multiple wavelengths with various parameters, or were left unspecified. CONCLUSION: Laser test spot methodology was diverse and performed for dual objectives of efficacy and safety. The authors have compiled clinical considerations to assist laser operators in deciding whether performing a test spot may be beneficial to their patient.

Surface gap solitons in the Schrödinger equation with quintic nonlinearity and a lattice potential.

We demonstrate the existence of surface gap solitons, a special type of asymmetric solitons, in the one-dimensional nonlinear Schrödinger equation with quintic nonlinearity and a periodic linear potential. The nonlinearity is suddenly switched in a step-like fashion in the middle of the transverse spatial region, while the periodic linear potential is chosen in the form of a simple sin 2 lattice. The asymmetric nonlinearities in this work can be realized by the Feshbach resonance in Bose-Einstein condensates or by the photorefractive effect in optics. The major peaks in the gap soliton families are asymmetric and they are located at the position of the jump in nonlinearity (at x = 0). In addition, the major peaks of the two-peak and multi-peak solitons at the position x = 0 are higher than those after that position, at x > 0. And such phenomena are more obvious when the value of chemical potential is large, or when the difference of nonlinearity values across the jump is big. Along the way, linear stability analysis of the surface gap solitons is performed and the stability domains are identified. It is found that in this model, the solitons in the first band gap are mostly stable (excepting narrow domains of instability at the edges of the gap), while those in the second band gap are mostly unstable (excepting extremely narrow domains of stability for fundamental solitons). These findings are also corroborated by direct numerical simulations.

Dark soliton families in quintic nonlinear lattices.

We prove that the dark solitons can be stable in the purely quintic nonlinear lattices, including the fundamental, tripole and five-pole solitons. These dark soliton families are generated on the periodic nonlinear backgrounds. The propagation constant affects the forms of these solitons, while the number of poles does not lead to the variation of the backgrounds. The dark solitons are stable only when the propagation constant is moderately large.

A Dual-Network Modeling Architecture for Statistical Evaluation of College Graduates' Working Ability in Consistence with Their Job Position and Remuneration.

Optimal human resources allocation asks to employ a person to work in the position corresponding to his/her ability. Employment competence is the key feedback to the cultivation of college students' working ability. The data relationship needs to analyze between the in-school cultivation items and the working abilities required by the companies. Machine learning framework is introduced to study the companies' responses to the cultivation of college students. In this work, a dual-network architecture is built up for statistical modeling evaluation of college graduates' working ability in consistence with their job position and remuneration. A requirement network and a cultivation network are constructed for extracting features from the original working ability data required by companies and cultivated ever in school. The networks are fully trained by adaptively tuning the linking weights. The extracted features are fused together to estimate the working competence of each target sample/person. To evaluate the dual-network model, a modeling index system is designed, including proposing a total evaluation index calculus for the dual-network model, and a variable importance index from the original data. The samples are consequently ranked by the model predicted index and by the variable importance index, respectively. The ranking difference is used to evaluate the prediction efficiency of the dual-network model. Experimental results show that the dual network architecture is feasible to establish statistical models for the evaluation of college graduates' in-school cultivated working ability in consistence with the company's required working ability at their job position and their deserved remuneration.

Suppression of the critical collapse for one-dimensional solitons by saturable quintic nonlinear lattices.

The stabilization of one-dimensional solitons by a nonlinear lattice against the critical collapse in the focusing quintic medium is a challenging issue. We demonstrate that this purpose can be achieved by combining a nonlinear lattice and saturation of the quintic nonlinearity. The system supports three species of solitons, namely, fundamental (even-parity) ones and dipole (odd-parity) modes of on- and off-site-centered types. Very narrow fundamental solitons are found in an approximate analytical form, and systematic results for very broad unstable and moderately broad partly stable solitons, including their existence and stability areas, are produced by means of numerical methods. Stability regions of the solitons are identified by means of systematic simulations. The stability of all the soliton species obeys the Vakhitov-Kolokolov criterion.

Association between migrant worker experience, limitations on insurance coverage, and hospitalization for schizophrenia in Hunan Province, China.

BACKGROUND: While transnational migration has been shown to be a risk factor for schizophrenia, studies have not examined whether massive internal rural-to-urban migration in China in recent years has increased the risk of hospitalization for schizophrenia, or schizophrenia symptom severity among migrants. METHOD: In a sample of patients acutely hospitalized with schizophrenia in Changsha, Hunan Province, China (N=334), the proportion of past migrant workers among patients was compared to the proportion of past migrant workers in the general adult population of Hunan. Past migrants were also compared to non-migrants on age of onset, and on symptom severity using the Positive and Negative Syndrome Scale (PANSS). The risk ratio for being a migrant among those hospitalized for schizophrenia was stratified by age and gender subgroups. Multiple regression analysis was used to evaluate group differences in age of onset and symptoms. RESULTS: Of 334 patients diagnosed with schizophrenia hospitalized for <180days, 150 (44.9%) were identified as having been migrant workers compared to 31.0% in the general adult population of Hunan for a risk ratio of 1.45, a risk that was higher for women (2.19) than for men (1.09). Migrant workers also had higher scores than others on total PANSS symptoms. CONCLUSION: Migrant workers appear to be at greater risk of hospitalization for schizophrenia than other residents of Hunan and showed more severe psychopathology. These findings may reflect specific lack of health insurance coverage for workers migrating to non-native provinces in China, thereby delaying access to treatment.

Assaying Carcinoembryonic Antigens by Normalized Saturation Magnetization.

Biofunctionalized magnetic nanoparticles (BMNs) that provide unique advantages have been extensively used to develop immunoassay methods. However, these developed magnetic methods have been used only for specific immunoassays and not in studies of magnetic characteristics of materials. In this study, a common vibration sample magnetometer (VSM) was used for the measurement of the hysteresis loop for different carcinoembryonic antigens (CEA) concentrations (Φ CEA) based on the synthesized BMNs with anti-CEA coating. Additionally, magnetic parameters such as magnetization (M), remanent magnetization (M R), saturation magnetization (M S), and normalized parameters (ΔM R/M R and ΔM S/M S) were studied. Here, ΔM R and ΔM s were defined as the difference between any Φ CEA and zero Φ CEA. The parameters M, ΔM R, and ΔM S increased with Φ CEA, and ΔM S showed the largest increase. Magnetic clusters produced by the conjugation of the BMNs to CEAs showed a ΔM S greater than that of BMNs. Furthermore, the relationship between ΔM S/M S and Φ CEA could be described by a characteristic logistic function, which was appropriate for assaying the amount of CEAs. This analytic ΔM S/M S and the BMNs used in general magnetic immunoassays can be used for upgrading the functions of the VSM and for studying the magnetic characteristics of materials.

WITHDRAWN: Formation of TCNM from polyDADMAC during UV irradiation combined with chlorination treatment.

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Effect of xanthone derivatives on animal models of depression.

BACKGROUND: Extracts of the plant Hypericum perforatum L. have been traditionally used in folk medicine for the treatment of depressive disorders. Xanthone, a component of Hypericum perforatum L., has been shown to be effective in animal models of depression. OBJECTIVE: We investigated if 2 xanthone derivatives (1101 and 1105) were as effective as venlafaxine, which is a serotonin-norepinephrine reuptake inhibitor and was used as a positive control, in animal models of depression. METHODS: A series of derivatives from xanthone were designed and synthesized. After preliminary experiments, 2 xanthone derivatives (1101 and 1105) were considered to be effective in our mouse depression model. To further determine their effects on depression, classical behavioral despair animal models (forced swim and tail suspension tests) were used to assess the efficacies of these derivatives, whereas venlafaxine hydrochloride was used as a positive control. Oral acute toxicity studies were used to determine if the derivatives were toxic in mice. RESULTS: The oral acute toxicity studies of 2 xanthone derivatives (1101 and 1105) did not show any toxic effect until the dose at 1000 mg/kg body weight, and xanthone derivatives 1101 and 1105 resulted in a significant decrease of the immobility period (in seconds) compared with the untreated control group during the forced swim test with rats (dose = 12 mg/kg; P < 0.05) and mice (dose = 25 mg/kg; P < 0.001). At lower doses, derivatives 1101 and 1105 also decreased the immobility period of rats and mice during the forced swim test but significant differences were only found in mice compared with the untreated control group (P < 0.05). No difference was found between the groups treated with xanthone derivatives and the positive control group during the swimming period in both mice (dose = 25 mg/kg) and rats (dose = 12 mg/kg) (P > 0.05). In the tail suspension test, derivatives 1101 and 1105 produced marked effects with regard to the motion of mice (P < 0.01 or 0.001, respectively) and the derivatives were also noted to have some effects on rats at a dose of 12 mg/kg (P < 0.05). Compared with the positive venlafaxine control group, no differences were found between those treated with either derivative 1101 or derivative 1105 and venlafaxine (P > 0.05). CONCLUSIONS: Within certain dose ranges, xanthone derivatives 1101 and 1105 have similar effects to venlafaxine hydrochloride in the treatment of depression as suggested by behavioral despair animal models using rats and mice.

Proanthocyanidins from grape seeds modulates the nuclear factor-kappa B signal transduction pathways in rats with TNBS-induced recurrent ulcerative colitis.

The aim of this study was to elucidate the molecular mechanisms involved in the therapeutic effects of proanthocyanidins from grape seeds (GSPE) on recurrent ulcerative colitis (UC) in rats. GSPE in doses of 100, 200, and 400mg/kg were intragastrically administered per day for 7 days after recurrent colitis was twice-induced by TNBS. The levels of GSH, as well as the activity of GSH-Px and SOD in colon tissues were measured by biochemical methods. The expression levels of tumor necrosis factor-α (TNF-α) and the nuclear translocation levels of nuclear factor-kappa B (NF-κB) in the colon tissues were measured by enzyme-linked immunosorbent assay methods. Western blotting analysis was used to determine the protein expression levels of inhibitory kappa B-alpha (IκBα), inhibitor kappa B kinase (IKKα/ß), phosphorylated IκBα and phosphorylated IKKα/ß. GSPE treatment was associated with a remarkable increased the activity of GSH-Px and SOD with GSH levels in TNBS-induced recurrent colitis rats as compared to the model group. GSPE also significantly reduced the expression levels of TNF-α, p-IKKα/ß, p-IκBα and the translocation of NF-κB in the colon mucosa. GSPE exerted a protective effect on recurrent colitis in rats by modifying the inflammatory response and promoting damaged tissue repair to improve colonic oxidative stress. Moreover, GSPE inhibited the TNBS-induced inflammatory of recurrent colitis though blocking NF-κB signaling pathways.