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J Hum Genet ; 59(8): 475-6, 2014 Aug.
Article in English | MEDLINE | ID: mdl-25007882

ABSTRACT

Severe acne presents sexual dimorphism in its incidence in Chinese population. It is more prevalent in males. To assess the possible Y chromosomal contribution to severe acne risk in Han Chinese males, we analyzed 2041 Y chromosomal SNPs (Y-SNPs) in 725 severe acne cases and 651 controls retrieved from our recent genome-wide association study data. After data filtering, we assigned 585 cases and 494 controls into 12 Y chromosomal haplogroups based on 307 high-confidence Y-SNPs. No statistically significant difference in the distribution of Y chromosomal haplogroup frequencies was observed between the case and control groups. Our results showed a lack of association between the incidence of severe acne and the different Y chromosomal haplogroup in the Han Chinese population.


Subject(s)
Acne Vulgaris/genetics , Asian People/genetics , Chromosomes, Human, Y/genetics , Polymorphism, Single Nucleotide/genetics , Acne Vulgaris/epidemiology , Genome-Wide Association Study , Haplotypes , Humans , Male
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