ABSTRACT
Cerebral hemodynamics has been studied rheoencephalographically in 39 infants early in the course of complicated pneumonia and in 19 healthy controls. The former exhibited phasic changes in cerebral circulation. On the disease day 3 and 10, a significant reduction in the blood flow took place. In children under 6 months of age cerebral circulation is less active than in those over 6 months throughout the whole acute period of complicated pneumonia.
Subject(s)
Cerebrovascular Circulation , Periodicity , Pneumonia/physiopathology , Acute Disease , Hemodynamics , Humans , Infant , Pneumonia/complications , Respiratory Insufficiency/etiology , Respiratory Insufficiency/physiopathology , Sepsis/etiology , Sepsis/physiopathology , Time FactorsABSTRACT
Blood rheology was assessed in 23 infants with acute pneumonia complicated with respiratory infectious toxicosis during hospitalization to intensive care wards, a control group consisted of 19 healthy infants. Plasma viscosity, red cell deformability, surface architectonics, and aggregation were studied. Patients developed increased plasma viscosity, marked reduction of red cell deformability, and increased aggregation index parallelled by reduced rate of aggregate formation. Changed red cell surface architectonics was associated with a reduced count of discocytes and parallel increase of echinocytes and cupola-like red cell forms. These data evidence marked disorders of blood rheology which should be not disregarded when choosing therapeutic policy.
Subject(s)
Pneumonia/blood , Toxemia/blood , Humans , Infant , Infant, Newborn , Pneumonia/complications , Rheology , Toxemia/etiologyABSTRACT
Study of red cell surface structure is a highly informative method for the assessment of the body status in health and disease. The authors have examined the surface red cell structure of infants in health and disease by phase-contrast and scanning electron microscopy and came to the conclusion on the high reliability of the data obtained by phase-contrast microscopy. They recommend this unsophisticated and informative method for clinical practice.