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Gan To Kagaku Ryoho ; 36(6): 1013-6, 2009 Jun.
Article in Japanese | MEDLINE | ID: mdl-19542727

ABSTRACT

The efficacy of aromatase inhibitors(AI)has been established for adjuvant and metastatic breast cancer. However, decision making regarding treatment becomes difficult after AI treatment. Recently, high-dose toremifene(HD-TOR, TOR 120 mg daily)showed efficacy in these patients. We attempted to study retrospectively the efficacy and safety of HD-TOR treatment. Seven patients received HD-TOR. The overall response rate was 29%(PR 2)and clinical benefit (CR, PR, long SD)was 57%(PR 2, long SD 7). HD-TOR may be an optional treatment for MBC after AI treatment.


Subject(s)
Antineoplastic Agents, Hormonal/administration & dosage , Aromatase Inhibitors/therapeutic use , Breast Neoplasms/drug therapy , Toremifene/administration & dosage , Aged , Aged, 80 and over , Drug Resistance , Female , Humans , Middle Aged , Retrospective Studies
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