Shape-Changing Particles: From Materials Design and Mechanisms to Implementation.

Demands for next-generation soft and responsive materials have sparked recent interest in the development of shape-changing particles and particle assemblies. Over the last two decades, a variety of mechanisms that drive shape change have been explored and integrated into particulate systems. Through a combination of top-down fabrication and bottom-up synthesis techniques, shape-morphing capabilities extend from the microscale to the nanoscale. Consequently, shape-morphing particles are rapidly emerging in a variety of contexts, including photonics, microfluidics, microrobotics, and biomedicine. Herein, the key mechanisms and materials that facilitate shape changes of microscale and nanoscale particles are discussed. Recent progress in the applications made possible by these particles is summarized, and perspectives on their promise and key open challenges in the field are discussed.

Formulation-based approaches for dermal delivery of vaccines and therapeutic nucleic acids: Recent advances and future perspectives.

A growing variety of biological macromolecules are in development for use as active ingredients in topical therapies and vaccines. Dermal delivery of biomacromolecules offers several advantages compared to other delivery methods, including improved targetability, reduced systemic toxicity, and decreased degradation of drugs. However, this route of delivery is hampered by the barrier function of the skin. Recently, a large body of research has been directed toward improving the delivery of macromolecules to the skin, ranging from nucleic acids (NAs) to antigens, using noninvasive means. In this review, we discuss the latest formulation-based efforts to deliver antigens and NAs for vaccination and treatment of skin diseases. We provide a perspective of their advantages, limitations, and potential for clinical translation. The delivery platforms discussed in this review may provide formulation scientists and clinicians with a better vision of the alternatives for dermal delivery of biomacromolecules, which may facilitate the development of new patient-friendly prophylactic and therapeutic medicines.

Active Reversible Swimming of Magnetically Assembled "Microscallops" in Non-Newtonian Fluids.

Miniaturized devices capable of active swimming at low Reynolds numbers are of fundamental importance and possess potential biomedical utility. The design of colloidal microswimmers requires not only miniaturizing reconfigurable structures but also understanding their interactions with media at low Reynolds numbers. We investigate the dynamics of "microscallops" made of asymmetric magnetic cubes, which are assembled and actuated using magnetic fields. One approach to achieving directional propulsion is to break the symmetry of the viscous forces by coupling the reciprocal motions of such microswimmers with the nonlinear rheology inherent in non-Newtonian fluids. When placed in shear-thinning fluids, the local viscosity gradient resulting from nonuniform shear stresses exerted by time-asymmetric strokes of the microscallops generates propulsive thrust through an effect we term "self-viscophoresis". Surprisingly, we found that the direction of propulsion changes with the size and structure of these assemblies. We analyze the origins of their directional propulsion and explain the variable propulsion direction in terms of multiple counterbalancing domains of shear dissipation around the microscale structures. The principles governing the locomotion of these microswimmers may be extended to other reconfigurable microbots assembled from colloidal-scale units.