Dynamics of LPO products and oxidative modification of proteins in human brain during postnatal development.

Opposite changes in the content of LPO products and products of oxidative modification of proteins were detected in human brain structures in the course of postnatal development. A clear-cut ontogenetic reduction of LPO products was observed in field 17 of the cortex, archicortex structures, and in the hypothalamus. Age-specific increase in the levels of products of oxidative modification of proteins was recorded in all compartments of the brain; it peaked by the age of 12-21 years and was most pronounced (4-6-fold) in the visual cortex, hippocampus, diencephalic and pontobulbar compartments of the brain.