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Objective@#To explore the efficacy of an individualized cardiac rehabilitation education model on the knowledge level of cardiac rehabilitation and cardiac rehabilitation exercise for patients after percutaneous coronary intervention (PCI).@*Methods@#This study adopted the method of quasi-experimental research, 96 patients after PCI were randomly divided into the intervention group (49 cases), and the control group (47 cases) according to the discharge order. The intervention group received the individualized education model of cardiac rehabilitation for 12 weeks led by the cardiac rehabilitation outpatient nurse, and the control group received the routine follow-up guidance. Before and after the intervention of the two groups, the changes of cardiac rehabilitation knowledge were evaluated according to The Coronary Artery Disease Education Questionnaire-II(CADE-Q II), the compliance of cardiac rehabilitation exercise were evaluated according to heart rate band mobile APP or mobile WeChat exercise APP, the effects of cardiac rehabilitation exercise were adjusted according to a 6-minute walking test.@*Results@#The increase scores of CADE-Q II in the intervention group after the intervention were higher than that in the control group:(10.04±2.75) points vs (5.57 ± 2.65) points, and the difference was significant (t=2.079, P < 0.05).The exercise compliance of daily aerobic exercise target rate indicated on the App of mobile phones in the intervention group were higher than that in the control group:88%(15/17) vs 53% (7/17), and the difference was significant (t=5.100, P <0. 05). The exercise compliance of daily exercises indicating on the Wechat application in the intervention group were higher than that in the control group: 82% (23/28) vs 48% (13/27), and the difference was significant (t=7.025, P <0.01).6MWD in the intervention group was higher than that in the control group: (48.77±26.67) mvs (16.77±43.65) m, and the difference was significant (t=3.534, P <0.01).@*Conclusion@#This cardiac rehabilitation education model can improve the knowledge level and compliance of cardiac rehabilitation exercise, and promote the cardiac rehabilitation of patients after PCI.
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Objective To explore the efficacy of an individualized cardiac rehabilitation education model on the knowledge level of cardiac rehabilitation and cardiac rehabilitation exercise for patients after percutaneous coronary intervention (PCI). Methods This study adopted the method of quasi-experimental research, 96 patients after PCI were randomly divided into the intervention group (49 cases), and the control group (47 cases) according to the discharge order. The intervention group received the individualized education model of cardiac rehabilitation for 12 weeks led by the cardiac rehabilitation outpatient nurse, and the control group received the routine follow-up guidance. Before and after the intervention of the two groups, the changes of cardiac rehabilitation knowledge were evaluated according to The Coronary Artery Disease Education Questionnaire- II(CADE- Q II), the compliance of cardiac rehabilitation exercise were evaluated according to heart rate band mobile APP or mobile WeChat exercise APP, the effects of cardiac rehabilitation exercise were adjusted according to a 6-minute walking test. Results The increase scores of CADE-Q II in the intervention group after the intervention were higher than that in the control group:(10.04±2.75) points vs (5.57 ± 2.65) points, and the difference was significant (t=2.079, P<0.05).The exercise compliance of daily aerobic exercise target rate indicated on the App of mobile phones in the intervention group were higher than that in the control group:88%(15/17) vs 53% (7/17), and the difference was significant (t=5.100, P <0. 05). The exercise compliance of daily exercises indicating on the Wechat application in the intervention group were higher than that in the control group:82% (23/28) vs 48% (13/27), and the difference was significant (t=7.025, P <0.01).6MWD in the intervention group was higher than that in the control group:(48.77±26.67)mvs(16.77±43.65)m, and the difference was significant (t=3.534, P<0.01). Conclusion This cardiac rehabilitation education model can improve the knowledge level and compliance of cardiac rehabilitation exercise, and promote the cardiac rehabilitation of patients after PCI.
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Objective To examine the expression of miR-210,miR-155 and miR-34a in the peripheral blood of patients with systemic lupus erythematosus (SLE) and to analyze their clinical significance.Methods One hundred and teenty-six SLE patients were divided into the stable group (n=35),mild active group (n=49),medium and severe active group (n =42) based on systemic lupus erythematosus disease activity index (SLEDAI) score.Meanwhile,40 subjects for healthy check-up were selected as controls.The clinical data of patients were collected.Complete blood count,liver and kidney function and immunological indexes were tested in patients and the lupus activity index was assessed.The expression level of miR-210,miR-155 and miR-34a were determined by real-time polymerase chain reaction.Furthermore,the correlation between their levels and clinical parameters such as erythrocyte sedimentation rate (ESR),C-reactive protein (CRP),SLEDAI score,were analyzed.The expression levels of miR-210,miR-155 and miR-34a in each group were compared by one-way analysis of variance (ANOVA).Correlation analysis was performed by non parametric Spearman test.The difference was statistically significant if P＜0.05.The diagnostic value of SLE was evaluated by the subjects characteristic (ROC) curve.Results The levels of miR-210 and miR-155 were no significantly differencet between the stable group (0.017±0.012);(0.150±0.101) and the control group (0.015±0.010);(0.071±0.034),but they were increased in mild active group (0.502±0.166);(1.521±1.138),medium and severe active group(1.237±0.584),(13.589±9.827) (F=124.321,70.065,P＜0.05).The average expression level of miR-34a in the control group,the stable group,the mild active group and the moderate and severe active group were (0.005±0.003),(0.249±0.137),(2.981±1.762) and (9.625±5.873) respectively,and showed a trend of increase in turn (F=75.688,P＜0.05).The expression level of miR-210,miR-155 and miR-34a was not significantly different between the LN group and the non LN group (P＞0.05).The R values of miR-210,miR-155,miR-34a and each index were IgG (0.347;0.518;0.482);IgA (0.463;0.635;0.379);IgM (0.287;0.392;0.336),ESR(0.317;0.428;0.369),C3(0.243;0.429;0.381),C4(0.317;0.513;0.429),ANA titer (0.462;0.594;0.527),Anti-ds-DNA antibodies (0.391;0.586;0.483),SLEDAI scores (-0.412;-0.558;-0.493),and there were significant correlations (P＜0.05).In patients with SLE,there was no significant correlation between hormone therapy alone or hormone plus immunosuppressive therapy (P＞0.05).The sensitivity and specificity of miR-210,miR-155,miR-34a in combination for the diagnosis of SLE reached 75.7％ and 72.3％,respectively.Conclusion The levels of miR-210,miR-155 and miR-34a in combination may be used as bio-markers for the diagnosis of SLE.
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Objective To evaluate the clinical efficiency of febuxostat on hyperuricemia and hyperlipidemia,provide evidences for the option of clinical treatment.Methods From Mar.2015 to Mar.2016,80 patients with hyperuricemia and hyperlipidemia were enrolled to this study,and they were randomly divided into observation group and control group by random number table,each group with 40 cases.The observation group received 40 mg of fenbuterol tablets once a day.The control group received 100 mg allopurinol tablets three times a day.The levels of serum uric acid,lipids,endothelium-soluble intercellular adhesion molecule-1 (sICAM-1) and endothelium (ET-1) were measured at the baseline,12 weeks after treatment and 24 weeks after treatment.Meanwhile,the liver and kidney function damage and adverse reactions were recorded.Results After treatment,the levels of uric acid,blood lipid,sICAM-1 and ET-1 were decreased in two groups,and there was significant difference between them (P＜0.05).The adverse effects of the two groups were transient.The incidence of liver or kidney damage,side effect of drug in observation group was lower than that in the control group,and there was no significant difference between the two groups (P＞0.05),except the incidence of rash.Conclusion Febuxostat intervention in treatment of patients with hyperuricemia and hyperlipidemia is safe and efficient.
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@#Objective To observe the effects of continuous rehabilitation exercise on emotion and quality of life after emergency percutaneous coronary intervention (PCI). Methods From June, 2013 to December, 2014, 95 acute myocardial infarction (AMI) patients underwent emergency PCI were divided into intervention group (n=47) and control group (n=48) randomly. The control group accepted routine medicine and rehabilitation exercise for a week, while the intervention group accepted incremental exercise in hospital and rehabilitation exercise intervention after discharged. They were assessed with Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS) and WHO Quality of Life-BREF (WHOQOL-BREF) 3 months, 6 months, 12 months after PCI, and the cardiovascular events were recorded. Results The scores of SAS and SDS declined in both groups after PCI (F>27.394, P<0.001), and were less in the intervention group than in the control group (F>2.681, P<0.05). Meanwhile, the physiological, psychological, social relations and environmental scores of WHOQOL-BREF increased in both groups (F>10.394, P<0.001), and the physiological, psychological, social relation scores were more in the intervention group than in the control group (F>2.671, P<0.05), but the environmental score was not significantly different (F<0.568, P>0.05). The incidences of angina pectoris (12.8% vs. 29.2%) and re-infarction (0 vs. 10.4%) were less in the intervention group than in the control group within 12 months after PCI (P<0.05). Conclusion Continuous rehabilitation exercise can improve the long-term emotion and quality of life in patients after emergency PCI, and prevent the cardiovascular events.
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Objective To investigate the relationship between the brachial‐ankle pulse wave velocity (baPWV) with the ca‐rotid arterial intima‐media thickness(IMT) and carotid artery plaque in the patients with type 2 diabetes mellitus(T2DM) and to analyze the related risk factors causing atherosclerosis .Methods A total of 426 patients with T2DM were collected and conduct the records of baPWV ,carotid artery ultrasound ,biochemical index detection andrelated risk factors record .The correlation between baPWV with carotid arterial IMT was analyzed .The patients were divided into the abnormal group and normal group according to the baPWV results .The carotid artery IMT ,carotid artery plaque and related risk factors were compared between the two groups . Results The DM duration ,systolic blood pressure ,diastolic blood pressure ,pulse pressure ,low density lipoprotein cholesterol (LDL‐C) ,number of atherosclerosis risk factors had statistically significant differences between the two groups (P0 .05) .The detection rate of plaque by carotid artery ultrasound had no statistically signifi‐cant difference between the two groups(P>0 .05);but the statistically significant difference was found in the number of plaque be‐tween the two groups(P<0 .01) ,the abnormal group was obviously more than the normal group;the normal IMT ratio had statisti‐cally significant difference between the two groups(P<0 .05) ,the normal group was obviously higher than the abnormal group .The IMT value had statistical difference between the two groups(P<0 .01) ,which in the abnormal group was significantly thickened compared with the normal group .The analysis of correlation between baPWV and IMT showed that IMT was positively correlated with baPWV(r=0 .228 ,P<0 .05) .Conclusion T2DM patients with reduced arterial elasticity could complicated with the obvious thickening of carotid arterial IMT and increase of plaque number .Combining baPWV with carotid arterial ultrasound examination can better conduct the arteriosclerosis evaluation .
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Objective To investigate the clinical pathologic characteristics and prognosis of bilateral breast cancer, and to determine whether clinical factors is related to p53 gene mutation.Methods Archival material was reviewed from 48 cases of bilateral breast cancar.The clinical and pathological features of bilateral breast cancer were compared and summarized.Immunohistochemical stains for P53 were performed on 33 cases of bilateral breast cancer, 141 cases of unilateral breast cancer were also examined as control.Results The five-year survival rate for bilateral breast cancer patients was 70.5％.The median age when bilatereral breast cancer first dignosed was 47.5 (range from 27 to 69).The median time interval between the first and the subsequent breast cancer diagnosis was 9.5 months.Invasive ductal breast carcinoma was the main pathologic type of bilateral breast cancer.88.5％ of bilateral breast cancer would have the same estrogen receptor (ER) status and 81.8％ would have the same human epidermal growth hormone receptor 2 (HER2) status between the first and secondary primary tumors.Mutation p53 was more common among the bilateral breast cancer patients compared with the unilateral breast cancer patients (45.5％ vs.26.2％, x2 =4.711 ,P =0.030).There was no difference on the overall survival between bilateral breast cancer with p53 (+) and p53 (-)(x2 =0.434,P =0.510).Conclusion The main pathologic type of bilateral breast cancer is invasive ductal breast carcinoma, there is a good match of the ER and HER2 status between the first breast cancer and the contralateral one.Bilateral breast cancer patients have a similar overall survial with the unilateral breast cancer.p53 mutation is more common among bilateral breast cancer patients than those with unilateral breast cancer.
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Women diagnosed with breast cancer have a significantly higher risk of developing contralateral breast carcinoma.When the dignosis ofbilateral breast cancer (BBC)is established,the challenges for the doctors are to determine contralateral breast carcinoma is metastasis or primary lesions.The pathological type,receptor status,biological behavior and the prognosis of bilateral breast cancer are the issues have to be considered.On the other hand,we discuss which type of breast cancer trend to be bilateral breast cancer,thus more effective follow-up and preventive procedures would be applied on this part of patients to improve their quality of life and the curative rate.
