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Effective cytochrome P450 (CYP) inhibitor isolated from thyme (Thymus saturoides) purchased from a Japanese market.

Brahmi, Zeineb; Niwa, Hitomi; Yamasato, Mio; Shigeto, Sakurako; Kusakari, Yuna; Sugaya, Kouichi; Onose, Jun-ichi; Abe, Naoki.

Biosci Biotechnol Biochem ; 75(11): 2237-9, 2011.

Article in English | MEDLINE | ID: mdl-22056445

ABSTRACT

A highly polymethylated flavone that effectively inhibited cytochrome P450s (CYPs) 1A2 and 3A4 (IC(50) = 2.41 and 1.71 µM) in vitro was isolated from thyme leaves (Thymus saturoides) purchased from a Japanese market. Its structure was spectroscopically identified as 4',5-dihydroxy-3',6,7,8-tetramethoxy flavone (8-methoxycirsilineol, 1). This is the first report describing a strong inhibitor of CYP1A2 and 3A4 isolated from Thymus saturoides.

Subject(s)

Cytochrome P-450 CYP1A2 Inhibitors , Cytochrome P-450 CYP3A Inhibitors , Enzyme Inhibitors/chemistry , Flavones/chemistry , Thymus Plant/chemistry , Enzyme Inhibitors/isolation & purification , Enzyme Inhibitors/pharmacology , Flavones/isolation & purification , Flavones/pharmacology , Humans , Plant Leaves/chemistry

ABSTRACT

Subject(s)

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