Effect of Hydrothermal and Vapor Thermal Treatments on Apatite Inductivity of Titanate Nanotubes on Anodized Ti-5Nb-5Mo Surface.

Although titanium (Ti) alloys have been widely employed as biomedical materials, they cannot achieve satisfactory osseointegration when implanted in the human body due to their biologically inert nature. Surface modification can enhance both their bioactivity and corrosion resistance. The present study employed a Ti-5Nb-5Mo alloy with a metastable α″ phase. This alloy may undergo phase changes after conventional high-temperature heat treatment, which can deteriorate its properties. This study heat-treated the anodized Ti-5Nb-5Mo alloy by using a low-temperature hydrothermal or vapor thermal method to analyze the effects of heat treatment on its apatite induction. The results revealed that the porous nanotube structure on the surface of the alloy was transformed into anatase nanoparticles after hydrothermal or vapor thermal treatment at 150 °C for 6 h. After immersion in simulated body fluid (SBF) for 7 days, the amount of apatite deposited on the surface of the vapor thermal-treated alloy exceeded that on the hydrothermal-treated alloy. Therefore, post-heat treatment of anodized Ti-5Nb-5Mo by using the vapor thermal method can enhance its apatite inductivity without altering its structure.

The first two cases of neurotoxocariasis in Taiwan.

Toxocariasis is a zoonosis disease with high sero-prevalence in Southeast Asian. Neurotoxocariasis has never been reported in Taiwan. Herein, we presented 2 cases of neurotoxocariasis. The first case is a 48-year-old man with febrile headache, rapid progressive cognitive problems and later thoracic myelitis. Meningeal enhancements on the corresponding sites were found on magnetic resonance imaging (MRI). Eosinophilic pleocytosis was present in peripheral blood and cerebrospinal fluid (CSF). A positive Toxocara canis larval excretory-secretory antigen (TcES)-based immunoblotting test for CSF confirmed the diagnosis. The second case is a 42-year-old woman of progressive headache with features of increased intracranial pressure. CSF analysis showed lymphocytic pleocytosis initially and eosinophilic pleocytosis later. Her brain MRI was normal. The diagnosis was confirmed by the presence of anti-TcES IgG in CSF. The two cases were soonly cured by mebendazole. Neurotoxocariasis presented a broad spectrum of neurological symptoms and the CSF profile can be non-eosinophilic pleocytosis. The prevalence of neurotoxocariasis may be seriously underestimated due to low awareness of physicians and lack of standard conventional diagnostic test in Taiwan. The two cases of neurotoxocariasis firstly reported in Taiwan will raise physician's awareness in recognizing this curable disease particularly in managing patients with aseptic meningitis or meningoencephalitis of undetermined pathogen.

Neural Mechanisms of Inhibitory Response in a Battlefield Scenario: A Simultaneous fMRI-EEG Study.

The stop-signal paradigm has been widely adopted as a way to parametrically quantify the response inhibition process. To evaluate inhibitory function in realistic environmental settings, the current study compared stop-signal responses in two different scenarios: one uses simple visual symbols as go and stop signals, and the other translates the typical design into a battlefield scenario (BFS) where a sniper-scope view was the background, a terrorist image was the go signal, a hostage image was the stop signal, and the task instructions were to shoot at terrorists only when hostages were not present but to refrain from shooting if hostages appeared. The BFS created a threatening environment and allowed the evaluation of how participants' inhibitory control manifest in this realistic stop-signal task. In order to investigate the participants' brain activities with both high spatial and temporal resolution, simultaneous functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) recordings were acquired. The results demonstrated that both scenarios induced increased activity in the right inferior frontal gyrus (rIFG) and presupplementary motor area (preSMA), which have been linked to response inhibition. Notably, in right temporoparietal junction (rTPJ) we found both higher blood-oxygen-level dependent (BOLD) activation and synchronization of theta-alpha activities (4-12 Hz) in the BFS than in the traditional scenario after the stop signal. The higher activation of rTPJ in the BFS may be related to morality judgments or attentional reorienting. These results provided new insights into the complex brain networks involved in inhibitory control within naturalistic environments.