ABSTRACT
INTRODUCTION: Dysphagia is frequently present in Parkinsonian syndromes and is associated with increased morbidity and mortality. Early identification of swallowing dysfunction is critical to minimize complications like aspiration pneumonia and malnutrition. Published prevalence rates for dysphagia in Parkinsonian syndromes vary widely with a very few studies from India. In this study we aimed to determine prevalence of dysphagia in Parkinson's disease and other Parkinson plus syndromes; to correlate it with severity of underlying illness and to determine the factors predicting dysphagia in patients of Parkinson's disease. METHODS: It was a prospective observational study performed over 18 months in the neurology clinic of tertiary care public teaching hospital in Mumbai. All patients of Parkinson's disease (PD) diagnosed by UKPDS criteria and all patients of Parkinson-plus syndromes diagnosed clinically were included in the study serially. Patients with cognitive dysfunction (MMSE<24) and those having other neurological or non-neurological causes of dysphagia were excluded from the study. Swallowing dysfunction was assessed by MASA scoring sheet. Disease severity of PD was assessed by modified Hoehn and Yahr scale. Peripheral oxygen desaturation after swallowing water was monitored by pulse-oxymetry; as a bedside test for micro-aspiration. The data was tabulated and analyzed. RESULTS: 70 patients were included in the study including 63 with PD, 5 with PSP and 2 with MSA. Dysphagia was present in 40 (57.4%). 27 had mild; 12 had moderate and 1 had severe dysphagia. In Parkinson's disease dysphagia was significantly associated with following predicting factors: age > 65 years, disease duration > 3 years, modified Hoehn and Yahr scale > 2 and MMSE < 27 (p < 0.001 for all). By multiple logistic regression analysis, the duration of disease and MMSE score were the independent predictors for dysphagia in Parkinson's disease. Severity of dysphagia directly correlated with severity of underlying disease demonstrated by decreasing MASA score with rising Hoehn and Yahr stage. CONCLUSIONS: Prevalence of dysphagia in Parkinsonian syndromes was overall 57.14%; being 55.16% in Parkinson's disease. Prevalence and severity of dysphagia showed direct correlation with severity of Parkinson's disease. Duration of disease and cognitive dysfunction are the independent predictors of dysphagia in Parkinson's disease.