ABSTRACT
Amino acid analysis and investigation of nitrogen, calcium and phosphorus balance were done in two groups of patients with renal failure and osteodystrophy on vitamin D metabolites and analogues treatment. The results of the investigation confirm vitamin D metabolites influence on free amino acid metabolism and on nitrogen, calcium, phosphorus balance. We observed significant decreases of blood amino acids and good influence on renal osteodystrophy in patients treated with vitamin D metabolites. Vitamin D metabolites didn't influence retention, urinary and fecal excretion of endogenous nitrogen in patients with renal failure.
Subject(s)
Calcifediol/therapeutic use , Fatty Acids, Nonesterified/blood , Hydroxycholecalciferols/therapeutic use , Kidney Failure, Chronic/metabolism , Kidney Failure, Chronic/therapy , Adolescent , Calcifediol/administration & dosage , Calcium/metabolism , Child , Chronic Kidney Disease-Mineral and Bone Disorder/blood , Chronic Kidney Disease-Mineral and Bone Disorder/metabolism , Chronic Kidney Disease-Mineral and Bone Disorder/therapy , Humans , Hydroxycholecalciferols/administration & dosage , Kidney Failure, Chronic/blood , Nitrogen/metabolism , Phosphorus/metabolism , Time FactorsABSTRACT
Amino acid analysis and investigation of nitrogen, calcium and phosphorus balance were done in two groups of the patients with renal failure and osteodystrophy on the Vitamin D metabolites and analogues treatment. The results of the investigation confirm vitamin D metabolites influence on free amino acid turnover and on nitrogen, calcium, phosphorus balance. We observed significant decreases of blood amino acids and good influence on renal osteodystrophy in patients treated with the vitamin D metabolites. Vitamin D metabolites didn't influence on the retention, urinary and fecal excretion of endogenous nitrogen in patients with renal failure.
Subject(s)
Calcium/blood , Kidney Failure, Chronic/drug therapy , Phosphorus/blood , Proteins/metabolism , Vitamin D/analogs & derivatives , Vitamin D/therapeutic use , Adolescent , Amino Acids/blood , Biomarkers/blood , Child , Chronic Kidney Disease-Mineral and Bone Disorder/blood , Chronic Kidney Disease-Mineral and Bone Disorder/complications , Chronic Kidney Disease-Mineral and Bone Disorder/drug therapy , Feces/chemistry , Humans , Kidney Failure, Chronic/blood , Kidney Failure, Chronic/complications , Nitrogen/blood , Nitrogen/urineSubject(s)
Rickets/drug therapy , Rickets/surgery , Acidosis, Renal Tubular/drug therapy , Acidosis, Renal Tubular/surgery , Adolescent , Child , Child, Preschool , Combined Modality Therapy , Drug Therapy, Combination , Fanconi Syndrome/drug therapy , Fanconi Syndrome/surgery , Follow-Up Studies , Humans , Hypophosphatemia, Familial/drug therapy , Hypophosphatemia, Familial/surgery , Remission InductionSubject(s)
Congenital Abnormalities/therapy , Genetic Diseases, Inborn/therapy , Metabolism, Inborn Errors/therapy , Child , Combined Modality Therapy , Congenital Abnormalities/etiology , Congenital Abnormalities/genetics , Genetic Diseases, Inborn/etiology , Genetic Diseases, Inborn/genetics , Hospitals, Special/organization & administration , Humans , Metabolism, Inborn Errors/etiology , Metabolism, Inborn Errors/genetics , MoscowABSTRACT
The authors present the results of complex drug and orthopaedic treatment of children with imperfect osteogenesis. 40 patients were treated with a somatotropic hormone, calcitrin and vitamin D metabolites (oxydevit and dihydrocholecalciferol). In 20 of these patients corrective osteotomies of the long bones of the lower extremities combined with metal osteosynthesis with rods and massive plates were performed. In a number of patients osteoplasty with long cortical allografts was made. After the treatment all the children were able to move independently either with the aid of unloading orthopaedic apparatuses (17 patients), or without them (3 patients).
