ABSTRACT
The objective of the present work was to study the tympanograms of the premature infants during the first year of their life and to determine the optimal time for performing high-frequency and low-frequency tympanometry in the babies of different gestational age. It was shown that the middle ear as an apparatus of the sound-transmitting system becomes to function stably by the 6th month of life although the mechanisms for regulation of stabilization develop only in the end of the first year. For this reason, tympanometry in the children of the gestational age 29 - 32 , 33 - 37 и 38 - 40 weeks should be performed using two frequencies of the probing tone (226 Hz and 1 kHz) up to the 6 months of life inclusive and from 28 weeks to 1 year.Key words: premature baby, tympanometry, acoustic function.
Subject(s)
Acoustic Impedance Tests/methods , Infant, Premature/physiology , Gestational Age , Humans , InfantABSTRACT
Knowledgebases can become an effective tool essentially raising quality of information retrieval in molecular biology, promoting the development of new methods of education and forecasting of the biomedical R&D. Knowledge-based technologies should induce "paradigm shift" in the life science due to integrative focusing of research groups towards the challenges of postgenomic era. This paper debates concept of the knowledgebase, which exploits web usage mining to personalize the access of molecular biologist to the Internet resources.
Subject(s)
Databases, Factual , Internet , Knowledge Bases , Molecular Biology/methods , Genome, Human , HumansABSTRACT
The cytogenetic status and activity of regulatory systems for stability of the cell genome were evaluated in patients with chronic viral persistence. Hepatitis B and C viruses damage the chromosome apparatus of peripheral blood lymphocytes. Cytogenetic instability of immunocompetent cells during chronic viral infection was associated with inhibition of DNA excision repair system and dysregulation of apoptosis in target cells.
