ABSTRACT
his article is devoted to the comparative analysis of polymorphism of genes of the detoxification system in premature newborns with birth weight less than 1500 g and gestational age less than 32 weeks, formed bronchopulmonary dysplasia (BPD) (n=50), and without signs of BPD (n=47). A positive association between the presence in the genotype of deletion variants of glutathioneS-transferases (GSTT1 and GSTÐ1) and risk of developing BPD in preterm infants.
Subject(s)
Bronchopulmonary Dysplasia , Infant, Very Low Birth Weight , Polymorphism, Genetic , Genotype , Humans , Infant , Infant, Newborn , Infant, PrematureABSTRACT
The study was carried out to analyze the content of Clara's cells protein in highly premature newborns with respiration disorders in neonatal period. The sample of 106 premature newborns of gestational age 26-32 weeks and body mass at birth 660-1500 g was examined. The concentration of Clara's cells protein in bronchoalveolar liquid and blood serum was higher in patients with inborn pneumonia as compared with children with respiratory distress syndrome. The low content Clara's cells protein in highly premature newborns with pneumonia was related with subsequent development of bronchopulmonary dysplasia.
Subject(s)
Infant, Premature/blood , Pneumonia/blood , Respiratory Distress Syndrome, Newborn/blood , Uteroglobin/blood , Bronchoalveolar Lavage Fluid , Bronchopulmonary Dysplasia/blood , Female , Humans , Infant, Newborn , PregnancyABSTRACT
A hundred and four neonatal infants underwent clinical and functional studies in early neonatality. The levels of nitrites and medium molecular-weight molecules were determined in cardiologically healthy neonatal infants and children with posthypoxic cardiopathy. The magnitude of increases in biochemical parameters was found to be associated with clinical type of cardiopathy: their level significantly elevates in transient myocardial ischemia, their values achieve the maximum level in neonatal pulmonary hypertension and in the presence of functioning fetal communications.
Subject(s)
Cardiomyopathies/blood , Fetal Hypoxia/blood , Hypertension, Pulmonary/blood , Myocardial Ischemia/blood , Nitrites/blood , Cardiomyopathies/congenital , Female , Humans , Infant, Newborn , Male , PregnancySubject(s)
Fetal Hypoxia/blood , Heart Diseases/blood , Nitrates/blood , Pregnancy Trimester, Third/blood , Adult , Biomarkers/blood , Female , Fetal Hypoxia/complications , Fetal Hypoxia/diagnosis , Heart Diseases/diagnosis , Heart Diseases/etiology , Humans , Infant, Newborn , Predictive Value of Tests , PregnancyABSTRACT
An analysis of surgical treatment of 142 patients with cancer of the colon and rectum included 32 emergency cases and 110 scheduled operations. Standard surgical methods only were used in 94 patients, the lymphotropic immunocorrection with myelopidum in the postoperative period was made in 48 patients. The use of lymphotropic immunocorrection was shown to considerably improve the immunological parameters and to decrease postoperative lethality.
Subject(s)
Adjuvants, Immunologic/administration & dosage , Colorectal Neoplasms/surgery , Oligopeptides/administration & dosage , Adult , Age Factors , Aged , Colectomy , Colorectal Neoplasms/immunology , Colorectal Neoplasms/mortality , Colostomy , Data Interpretation, Statistical , Female , Humans , Male , Middle Aged , Postoperative Period , Sex FactorsSubject(s)
Coma/drug therapy , Diabetic Ketoacidosis/complications , Oxidants/administration & dosage , Sodium Hypochlorite/administration & dosage , Blood Glucose/metabolism , Coma/blood , Coma/etiology , Diabetic Ketoacidosis/blood , Diabetic Ketoacidosis/drug therapy , Drug Therapy, Combination , Female , Humans , Hypoglycemic Agents/administration & dosage , Infusions, Intravenous , Insulin/administration & dosage , MaleSubject(s)
Diabetic Coma/therapy , Sodium Hypochlorite/administration & dosage , Acute Disease , Adolescent , Adult , Aged , Combined Modality Therapy , Critical Care/methods , Diabetes Mellitus, Type 1/complications , Diabetes Mellitus, Type 1/metabolism , Diabetes Mellitus, Type 2/complications , Diabetes Mellitus, Type 2/metabolism , Diabetic Coma/metabolism , Diabetic Ketoacidosis/metabolism , Diabetic Ketoacidosis/therapy , Female , Humans , Infusions, Intravenous , Male , Middle Aged , Time FactorsSubject(s)
Critical Care , Diabetic Coma/therapy , Diabetic Ketoacidosis/therapy , Combined Modality Therapy , Diabetic Coma/diagnosis , Diabetic Coma/metabolism , Diabetic Ketoacidosis/diagnosis , Diabetic Ketoacidosis/metabolism , Diagnosis, Differential , Fluid Therapy , Humans , Insulin/therapeutic useABSTRACT
Effects of nitroprusside, nitroglycerin, propranolol and mannitol on the size of infarcted and peri-infarction areas were examined in 276 patients with acute left-ventricular anterior myocardial infarction. The study involved an assessment of electrocardiograms from 35 precordial leads, and the measurement of central venous blood pressure, hemodynamic parameters, serum enzymes, acid-base state and, in some patients, the pressure inside the pulmonary artery, right and left cavities of the heart and the aorta, left-ventricular kinetocardiography, etc. All the drugs examined were shown to have a favourable effect on the size of the peri-infarction area and reduce the extent of myocardial infarction. Indications for each of the drugs have been worked out on a differential basis. A detailed analysis of ECG patterns from multiple chest leads under the action of nitroprusside, nitroglycerin, propranolol and mannitol is presented.
