1.
Bioorg Med Chem Lett
; 18(7): 2288-91, 2008 Apr 01.
Article
in English
| MEDLINE
| ID: mdl-18353639
ABSTRACT
Novel diamine derivatives containing imidazolidinylidene propanedinitrile were synthesized and evaluated for histamine H(3) receptor-binding affinities. High-affinity ligands 3d, 3k, and 3n showed potent H(3) receptor antagonism and excellent selectivity over human H(1), H(2) and H(4) receptors.