Auxiliary delivered school based oral health promotion among 12-14-year-old children from a low resource setting-A cluster randomized trial.

OBJECTIVES: This community intervention study compared the changes in oral health knowledge, attitude, practices (KAP), and oral health indicators among 12-14-year-old children who received a school based oral health promotion delivered by auxiliaries in a rural setting in India. METHODS: The interventions in this school based cluster randomized trial were delivered using schoolteachers and school health nurses. Oral health education (once in 3 months), weekly classroom based sodium fluoride mouth rinsing and biannual oral health screening/ referral were provided for 1 year. The control arm did not receive these interventions. Oral health indicators and self-administered KAP questionnaire were evaluated at baseline and 1-year follow-up. Oral health indicators included oral hygiene index simplified, DMFT/DMFS net caries increments, prevented fraction, number of sites with gingival bleeding, changes in care index, restorative index, treatment index, and dental attendance. RESULTS: The improvement in total KAP score, oral hygiene, and gingival bleeding from baseline to follow up was higher in the intervention arm (p < 0.05). The prevented fraction for net caries increment were 23.33% and 20.51% for DMFT and DMFS, respectively. Students in the intervention group had a higher dental attendance (OR 2.92, p < 0.001). The change in treatment index, restorative index, and care index were significantly higher in the intervention arm (p < 0.001). CONCLUSIONS: Inclusion of available primary care auxiliaries like school health nurses and teachers in oral health promotion is a novel, effective, and sustainable strategy to improve oral health indicators and utilization in rural areas in low resource settings.

Self-perception on oral health and related behaviours among antenatal mothers attending a public antenatal clinic - Kerala.

BACKGROUND AND AIMS: Antenatal oral care has been given least priority on a global scale. The study assesses self-perception of oral health knowledge and related behaviors among antenatal mothers. METHOD: A cross-sectional study was done among 400 pregnant women attending antenatal care clinic of a tertiary care center in Kerala, India. Details regarding knowledge, attitude, and practice were obtained, after getting an informed consent. The dental caries experience and gingival status were measured. To test the significance (p ≤ 0.05) between variables, Chi-square test was used. RESULTS: Poor oral health knowledge was observed among 75.5% of the pregnant mothers. Oral health problems were reported by 63.2% of them. Low priority for oral health (59.4%) and fear for fetal safety (17.5%) were the reasons for delaying dental services. Oral examination showed that more than half of the study subjects had a high prevalence of dental caries (67.5%) and low gingival bleeding status (26.2%). The study highlights that more than half of the study population (60.8%) were influenced by the elderly in the family to avoid certain food items. A better oral health knowledge was observed among the upper middle class (OR - 2.8) who had visited dentists within the last six months (OR - 3.6) and child bearing mothers (OR- 0.46) (p ≤ 0.05).

Translation and validation of oral health impact profile-14 questionnaire into Indian sign language for hearing-impaired individuals.

OBJECTIVES: To translate and cross-culturally adapt the oral health impact profile-14 (OHIP-14) questionnaire into Indian sign language (ISL) using a video format and to evaluate its psychometric properties. METHODS: The study was conducted among hearing-impaired individuals attending the National Institute of Speech and Hearing, Thiruvananthapuram, Kerala. The OHIP-14 was translated to ISL in a video format. The content validity and face validity were assessed. The final questionnaire was renamed as OHIP-12 ISL and was administered on 120 hearing-impaired individuals. Oral health indicators, OHIP-12 ISL scores, and a single-item global question (GQ) scores were used for construct validity assessment. Internal consistency and test-retest reliability were assessed using Cronbach's alpha and intraclass correlation (ICC) coefficient. Discriminant validity was assessed by comparing OHIP-12 ISL scores with oral health indicators by using Mann-Whitney U test and Fischer's exact test. Convergent validity was assessed by correlating OHIP-12 ISL scores with GQ scores and oral health indicators by using Spearman's rank correlation coefficient. RESULTS: The OHIP-12 ISL demonstrated high Cronbach's alpha (α = 0.80). Average ICC coefficient was 0.98 (0.97-0.99) and demonstrated acceptable construct validity. CONCLUSIONS: Translated and culturally adapted OHIP-12 ISL is a valid and reliable instrument to measure the OHRQoL among hearing impaired in India.

Diaphragmatic hernia following oesophagectomy for oesophageal cancer - Are we too radical?

BACKGROUND: Diaphragmatic herniation (DH) of abdominal contents into the thorax after oesophageal resection is a recognised and serious complication of surgery. While differences in pressure between the abdominal and thoracic cavities are important, the size of the hiatal defect is something that can be influenced surgically. As with all oncological surgery, safe resection margins are essential without adversely affecting necessary anatomical structure and function. However very little has been published looking at the extent of the hiatal resection. We aim to present a case series of patients who developed DH herniation post operatively in order to raise discussion about the ideal extent of surgical resection required. METHODS: We present a series of cases of two male and one female who had oesophagectomies for moderately and poorly differentiated adenocarcinomas of the lower oesophagus who developed post-operative DH. We then conducted a detailed literature review using Medline, Pubmed and Google Scholar to identify existing guidance to avoid this complication with particular emphasis on the extent of hiatal resection. DISCUSSION: Extended incision and partial resection of the diaphragm are associated with an increased risk of postoperative DH formation. However, these more extensive excisions can ensure clear surgical margins. Post-operative herniation can be an early or late complication of surgery and despite the clear importance of hiatal resection only one paper has been published on this subject which recommends a more limited resection than was carried out in our cases. CONCLUSION: This case series investigated the recommended extent of hiatal dissection in oesophageal surgery. Currently there is no clear guidance available on this subject and further studies are needed to ascertain the optimum resection margin that results in the best balance of oncological parameters vs. post operative morbidity.

Reduction in gastric cancer surgical mortality over 10 years: An adverse events analysis.

BACKGROUND: The reduction in gastric cancer mortality is due to a reduction in incidence and of surgical mortality. This study was to examine adverse events in patients with gastric cancer dying under surgical care. METHODS: Adverse events in surgical care were prospectively audited in patients who died of gastric cancer in Scottish hospitals. A cohort retrospective study examining deaths and contributing adverse events was compared for the periods 1996-2000 and 2001-2005. RESULTS: Between 1996 and 2005, 1083 patients with gastric cancer died on surgical wards in Scottish hospitals. The annual number of deaths under surgical care fell significantly from an average of 128 deaths per annum in years 1996-2000 to 88 deaths per annum in 2001-2005 (p < 0.001). This occurred in parallel with the decline in gastric cancer incidence over the same period. There was an increase in the proportion of gastric cancer resections carried out in 7 major hospitals in Scotland in the second period of the study (p < 0.001). The mean number of deaths in the group of patients, who had gastric cancer resection and palliative surgery, were significantly lower in the second period of the study In addition, when all patients were considered as a group, the mean number of anaesthetic, critical care, medical management and technical surgery adverse events were significantly lower in the second study period. CONCLUSION: There has been a reduction in deaths and adverse events for patients with gastric cancer under surgical care and this has been associated with surgical subspecialisation in oesophago-gastric cancer surgery.

Improved short term surgical outcomes in Scotland for oesophageal cancer.

AIM: This study examined the trends in mortality and contributing adverse events associated with death under surgical care for patients with oesophageal cancer. METHODS: Adverse events in surgical care were prospectively audited in patients who died with cancer of the oesophagus or oesophago-gastric junction under surgical care in Scotland from 1994 to 2005 through the Scottish Audit of Surgical Mortality (SASM). RESULTS: Between 1994 and 2005 (inclusive), 1424 patients with oesophageal cancer (median age 72, 62% male) died. The proportion of oesophageal cancer patients dying on a surgical ward fell significantly from 17% to 13% (p = 0.005). There has been a significant decrease in the annual number of major surgical resections for oesophageal cancer in Scotland from 324 in 1994 to 193 in 2005 (p < 0.001). The proportion of patients operated on in specialist cancer centres increased since 2000. In the period 1996 to 2005, 1157 patients died under surgical care with oesophageal cancer and were audited by SASM. One hundred and thirty five patients (12%) had 239 adverse events. Overall, the number of adverse events decreased over time with 65/130 of those who died following a cancer resection had adverse events. An anastomotic leak was a factor in 25 of these patients. There was a significant decrease in the proportion of deaths following therapeutic endoscopy (p = 0.011). CONCLUSION: There has been a significant decrease in the number of cancer resections, adverse events and mortality associated with oesophageal cancer surgery at a time of increasing surgical specialisation.

Routine diagnostic laparoscopy reduces the rate of unnecessary appendicectomies in young women.

BACKGROUND: The reported negative appendicectomy rate for young women remains high. This high rate of unnecessary appendicectomies has morbidity and high cost. Consensus European Association of Endoscopic Surgeons (EAES) guidelines have emphasised the value of routine laparoscopy as a diagnostic tool in young women. The objective of this study is to investigate the role of routine laparoscopy in the diagnosis of suspected appendicitis in young women. METHODS: The details of young female patients who have had an appendicectomy with or without laparoscopy between 1980 and 2005 were obtained. The histopathological reports pertaining to the episode of appendicectomy were manually searched. Three periods were identified for comparison. The first period was between 1980 and 1990 when diagnostic laparoscopy was not practised in the emergency setting. The second period was between 1991 and 1999 when diagnostic laparoscopy was used selectively. The third period was between 2000 and 2005 when diagnostic laparoscopy was used routinely to investigate female patients presenting with acute right iliac fossa pain. RESULTS: Selective laparoscopy reduced the rate of negative appendicectomy rate from 37% to 31% (ns). By contrast, routine laparoscopy reduced the negative appendicectomy rate to 5% (p < 0.005). Additionally, considering the ratios of all appendectomies to normal appendices, an average of one in three appendices excised was normal before the era of laparoscopy. The selective use of laparoscopy did not significantly alter this ratio (ns). By contrast routine use of laparoscopy has altered the ratio to 1 in 20 appendices removed to be normal (p < 0.001). CONCLUSION: In young females, diagnostic laparoscopy used selectively reduces the rate of negative appendicectomy but not significantly. However, when used routinely, laparoscopy significantly reduces the rate of negative appendicectomy. Diagnostic laparoscopy should be used routinely for all young females presenting with right iliac fossa pain sufficiently severe to warrant surgical exploration.

Long-term comparative outcome between laparoscopic total Nissen and Toupet fundoplication: Symptomatic relief, patient satisfaction and quality of life.

BACKGROUND: Laparoscopic antireflux surgery has become an established method of treatment of gastroesophageal reflux disease. This study compares the long-term outcome of total (Nissen) and partial (Toupet) fundoplication, performed in a single institution, by evaluating symptoms and quality of life. METHODS: 266 patients who underwent laparoscopic Nissen or Toupet fundoplication completed a preoperative reflux symptom questionnaire. Postsurgery symptom evaluation, patient satisfaction and quality of life in reflux and dyspepsia (QOLRAD) questionnaires were sent to these patients in December 2004. The two groups were compared for each item nonparametrically. RESULTS: Completed questionnaires were received from 161 patients (61%) of whom 99 had a laparoscopic Nissen fundoplication and 62 laparoscopic Toupet fundoplication. Both procedures were equivalent in improving reflux symptom scores in the long term, 79/99 (80%) and 56/62 (90%) were either symptom free or had obtained significant symptomatic relief. Both groups had equivalent QoL scores on the QOLRAD questionnaire. An equivalent number of patients (86% and 83.9% after Nissen and Toupet, respectively) were sufficiently satisfied to recommend antireflux surgery to a friend or relative complaining of reflux symptoms. CONCLUSION: In conclusion, in patients who have returned the questionnaire, long-term satisfaction, general symptom scores, and quality of life are equivalent after laparoscopic Nissen (complete) or Toupet (partial) fundoplication. There is however, a significant increased prevalence of persistent heartburn after laparoscopic Toupet fundoplication.

Free radical production in the esophago-gastro-duodenal mucosa in response to acid and bile.

Several studies have demonstrated the role of free radicals in causing esophagus-gastro-duodenal mucosal injury. The present study has been designed to investigate: whether acid, bile salts and a combination of bile + acid could determine the production of O2-derived free radicals by oesophageal, gastric and duodenal mucosa; which agent is capable of producing more free radicals and if O2-derived free radicals production depends on the duration of contact with acid, bile salts and their combination. Wistar rats' gastro-intestinal mucosa were perfused with bile, acid and a combination of bile + acid at pH4 and pH2 for 1 hour and 2 hours. Free radical production (FRP) was assessed by chemoluminescence. After 1 hour, the increase in FRP in comparison with control reached statistical significance (P < 0.05) at all tested pH levels in the duodenum, at pH1, 2 and 3 in the esophagus, and at pH1 in the stomach. Comparing different segments, both the esophagus and duodenum behaved similarly, producing more free radicals than the stomach at all pH values. However, this difference reached statistical significance at pH1 and 2 only. In comparison to control, FRP was increased by bile (pH7) infusion after 1 and 2 hours. There was increased FRP in all segments after the infusion of bile at pH2 and 4 in comparison to control. Infusion of bile at pH2 stimulates more FRP than infusion of bile at pH4 in all segments. This increased FRP reaches statistical significance in the esophagus after 2 hours of infusion, in the stomach after 1 and 2 hours of infusion, but in the duodenum it does not reach statistical significance. Acid, bile and bile + acid at pH2 and 4 can cause free radical production in esophageal, gastric and duodenal mucosa. Their role in producing free radicals is different according to the segment and the chemical composition of the solution.

Skin wound closure with a novel shape-memory alloy fixator.

BACKGROUND: Previously, we have described novel, thermally deployable tissue fixators based on the shape-memory properties of nickel titanium. The present study reports on the in vivo wound closure with these fixators as a preliminary to evaluating their use for bowel anastomoses. METHODS: Twenty adult Sprague-Dawley rats had 2.0-cm dorsal skin incisions approximated either with shape-memory alloy (SMA) fixators or conventional skin staples on a random basis. Electrical resistance heating was used to transform and deploy the SMA fixators into the wound. The rats were killed on day 14 or day 28 and wound specimens were harvested for force distraction studies and histologic examination. RESULTS: There was no incidence of wound dehiscence. 14- and 28-day wounds from both groups showed no significant difference in breaking force or energy. Histology revealed appropriate stages of wound healing for both SMA-closed and control wounds. CONCLUSIONS: The results confirm the efficacy and safety of tissue-edge approximation with SMA fixators.

Integrated waste management for rural development in Egypt.

Rural areas generate a large amount of plant and animal residues that can be recycled and utilized instead of relocation and/or burning. This will lead to increasing the benefits from agricultural sector in rural communities and ensuring a better environment. To increase the economic output and environmental benefits of recycling agricultural residues, integrated system should be considered, e.g., energy--compost-recycled water system; composting--co-composting system; food-feed compost system, ensilage of crop residues. The present work was a pilot study for optimizing integrated systems for bioconversion agricultural residues completed by establishing a Training Center for Recycling Agricultural Residues (TCRAR) thereby ensuring the dissemination of the technical, environmental, and socioeconomic aspects to farmers, live stock producers, extensions service staff, and private sector. Three integrated subsystems for bioconversion of agricultural residues were developed. They were based on (i) energy--manure-recycled water system, (ii) composting and co-composting system, and (iii) food-feed/compost system.

Self-expanding metallic stents in the management of advanced esophageal cancer: a review.

Palliation of advanced esophageal cancer continues to be a challenge to clinicians. Self expanding metal stents have been used in the esophagus for palliation of advanced esophageal cancer since 1983. They are relatively easy to insert by practicing endoscopists and have low rates of early complications. Delayed complications necessitating reintervention can arise in as many as a third of patients. The majority of stents are placed under sedation using endoscopy and fluoroscopy. Once deployed, they expand in the esophagus causing pressure necrosis on the wall of the esophagus. Several stents are available on the market with newer designs continuing to emerge. Choice of stent seems random among clinicians. Stents have been used for the management of esophageal obstruction including cervical esophageal obstruction and obstruction at the esophagogastric junction, tracheopulmonary fistulae, and mediastinal esophageal compression. Complications include chest pain, deployment and expansion problems, stent migration, tumor overgrowth and ingrowth, gastroesophageal reflux, and stent-related hemorrhage. Despite their high cost, stenting produce better palliation and some cost savings in comparison to conventional methods of palliation. Combination therapy using stenting followed by chemo/radio therapy may increase quality survival.

Effective hepatic cryoablation: does it enhance tumor dissemination?

This experimental study was designed to investigate the risk of tumor dissemination by hepatic cryosurgery and to determine the final subzero temperature required for effective hepatic tumor cryoablation. Although cryosurgery is now one of the established modalities for the treatment of some liver tumors and has been used for two decades, controversy remains regarding the final subzero temperature needed to destroy tumor masses. One experimental report has indicated that hepatic cryosurgery may enhance tumor dissemination. For this study, rat hepatic tumors were produced by direct injection of rat colonic carcinoma cells (DHD/K12/TRb). The control untreated animals (n = 12) were sacrificed after induction of liver tumors at 4 and 6 weeks. The animals in the treatment group (n = 16) underwent cryosurgery 2 weeks after tumor induction and were allowed to recover before sacrifice 2 and 4 weeks later. Pulmonary metastases were identified in 9 of 12 (75%) control animals at postmortem examination (2 and 6 weeks after tumor inoculation) and in 6 of 16 (38%) rats in the treatment group at sacrifice 2 and 4 weeks after cryosurgery (p = 0.11, Fisher's test for unpaired analysis). Peritoneal deposits were observed in 5 of 12 (42%) control animals at postmortem examination and in 8 of 16 (50%) of the treated animals at the time of cryosurgery (p = 0.95, Fisher's test for unpaired analysis). Two other study animals developed deposits after cryosurgery. The prevalence of peritoneal deposits in the study group was not altered by cryosurgery (p = 0.5, McNemar's test for paired analysis). The importance of the final subzero temperature at the edge of the iceball during tumor ablation by cryosurgery was confirmed by the histologic findings. Complete ablation with no residual viable tumor was obtained only when the subzero temperature had reached -38 degrees C or below. The results of this study do not support the suggestion that hepatic cryosurgery enhances tumor dissemination. The findings also confirm that a subzero temperature at the edge of the iceball of -38 degrees C or lower is necessary to ensure complete ablation of tumor.

Thermal characteristics of a hepatic cryolesion formed in vitro by a 3-mm implantable cryoprobe.

The objective of the investigation was to characterize the hepatic cryolesion formed with an implantable needle (3 x 100 mm) cryoprobe. This was used to produce cryolesions in isolated porcine liver tissue equilibrated to 37 degrees C in a water bath. The shape, size, and temperature zones within the cryolesion and the effect of single versus repeated freeze-thaw cycles on cryolesion size were studied. The final shape of the cryolesion at 15-20 min freezing was cylindrical and its distal hemispherical end extended 8 mm beyond the tip of the cryoprobe. The rate of increase in maximum diameter was logarithmic and decreased from 4.7 mm/min during the first 5 min to 0.4 mm/min during the fourth 5-min period of freezing. By contrast, the rate of increase in volume was linear and ranged from 9.6 to 7.9 ml/min during the corresponding periods. The volume of the hepatic cryolesion after 20 min of continuous freezing was significantly greater than that of the cryolesion formed with 20 min of cumulative freezing interrupted by a 5-min spontaneous thaw. The ultimate temperatures reached and the cooling rates varied in different zones within the cryolesion depending on distances away from and alongside the cryoprobe. Diameter measurements taken in isolation do not reflect the actual growth rate of the cryolesion. Volume measurements define more accurately the amount of tissue frozen and left in situ. Prolonged freezing beyond 20 min did not increase the diameter of the cryolesion. A single continuous freeze produces a larger cryolesion than two freeze-thaw cycles of the same freezing duration.

Task performance in endoscopic surgery is influenced by location of the image display.

OBJECTIVE: To investigate the influence of image display location on endoscopic task performance in endoscopic surgery. SUMMARY BACKGROUND DATA: The image display system is the only visual interface between the surgeon or interventionist and the operative field. Several factors influence the correct perceptual processing and endoscopic manipulation from images. One of these is location of the image display with respect to the surgeon and to the operative site. The present study was conducted to investigate whether endoscopic task performance improves under two conditions: when the surgeon-to-monitor visual axis is aligned with the forearm-instrument motor axis and when the image display is close to the operator's manipulation workspace. METHODS: An endoscopic task (tying an intracorporeal surgeon's knot) was performed under standardized conditions except for varying monitor locations. These altered the direction of view--in front of, to the left, and to the right of the operator's head and hands. In each of these view directions, the monitor was placed at the surgeon's eye level and lower down, at the level of the operator's hands. The outcome measures were the execution time, knot quality score and performance quality score. RESULTS: Task performance was better with frontal view direction: execution time was shorter (p < 0.0001) and the performance score was higher (p < 0.005) than with side viewing, with no significant difference between right and left viewing directions. With frontal view direction, hand-level "gaze-down" viewing resulted in a shorter execution time (p < 0.01) and a higher performance score (p < 0.01) than eye-level viewing. CONCLUSIONS: Task performance improves when the image display is placed in front of the operator, at a level below the head and close to the hands.

Cytotoxicity of electro-surgical smoke produced in an anoxic environment.

BACKGROUND: The effect on cell viability of smoke produced during high-frequency electro-surgery has not been previously reported. The aim of this study was to produce smoke in vitro, in a closed environment similar to that encountered in minimal access surgery, and to test its cytotoxic effects on cultured cells. METHODS: Pig liver was cut repeatedly with an electro-surgical hook knife, and the smoke generated was collected and equilibrated with cell culture medium. MCF-7 human breast carcinoma cells were exposed briefly to various dilutions of this medium and tested for clonogenicity. RESULTS: Electro-surgical smoke produced in a helium environment reduced the clonogenicity of the MCF-7 human breast carcinoma cells in a dose-dependent manner, falling to 30% when the cells were exposed to undiluted medium for 15 minutes. CONCLUSIONS: We conclude that electro-surgical smoke is cytotoxic. The sublethal effects at lower dilutions are currently being investigated.

Does laparoscopic cardiomyotomy require an antireflux procedure?

BACKGROUND AND STUDY AIMS: There is controversy concerning the need for an antireflux procedure in patients undergoing open or endoscopic cardiomyotomy for achalasia. The addition of an antireflux wrap (partial or total), while preventing reflux, may result in persistence or incomplete relief of dysphagia in patients with total oesophageal aperistalsis. The technique of laparoscopic cardiomyotomy used in Dundee preserves the lateral and posterior attachments of the gastro-oesophageal junction, and was designed to minimize the risk of gastro-oesophageal reflux. PATIENTS AND METHODS: A consecutive series of patients with achalasia (n = 19) were treated by laparoscopic cardiomyotomy using the Dundee technique, which limits the mobilization to the anterior wall of the abdominal and thoracic oesophagus. The patients were followed up prospectively to assess the long-term relief of dysphagia and the postoperative incidence of reflux symptoms, with or without oesophagitis. RESULTS: The follow-up symptoms and assessment of the patients (15-53 months, median 27 months) showed total relief (n = 12) or substantial relief (n = 5) of dysphagia in 89%. On assessment at a median follow-up of 27 months, the number of patients experiencing heartburn after this operation increased from four of 15 to five of 15, and one patient (6.6%) developed endoscopically proved oesophagitis, with a positive oesophageal pH monitoring test. CONCLUSIONS: The routine addition of an antireflux operation is not justified in patients undergoing laparoscopic cardiomyotomy, provided that the lateral and posterior attachment of the oesophagus are kept intact.

Randomised study of influence of two-dimensional versus three-dimensional imaging on performance of laparoscopic cholecystectomy.

BACKGROUND: Several three-dimensional video-endoscopic systems have been introduced to enhance depth perception during minimum-access surgery. However, there is no conclusive evidence of benefit, and these systems are more expensive than conventional two-dimensional systems. We undertook a prospective randomised comparison of two-dimensional and three-dimensional imaging in elective laparoscopic cholecystectomy for symptomatic gallstone disease. METHODS: The operations were done by four specialist registrars as part of their higher surgical training. 60 operations were randomised for execution by either two-dimensional or three-dimensional imaging display (30 by each method). The degree of difficulty of the operation was graded by a consultant surgeon on a standard grading system. The primary endpoints were execution time and the errors made during the procedure. The secondary endpoints were subjective assessment of the image quality and adverse effects on the surgeon. FINDINGS: There was no difference between the two-dimensional and three-dimensional display groups in median execution time (3160 [IQR 2735-4335 vs 3100 [2379-3710] s; p = 0.2) or error rate (six vs six). Surgeons reported adverse symptoms immediately after the operations with both systems. The scores for visual strain, headache, and facial discomfort were higher with the three-dimensional system. INTERPRETATION: With the current technology, three-dimensional systems based on sequential imaging show no advantage over two-dimensional systems in the conduct of laparoscopic cholecystectomy.

Laparoscopic common bile duct exploration after failed endoscopic stone extraction.

BACKGROUND AND STUDY AIMS: Despite the documented success rate and safety of laparoscopic ductal stone extraction, the majority of patients are treated with preoperative endoscopic stone extraction followed by laparoscopic cholecystectomy. When this fails, conventional open cholecystectomy and common bile duct exploration are performed. We report here a series of patients who were treated laparoscopically after failed attempts at endoscopic stone extraction. PATIENTS AND METHODS: Nineteen patients (12 women and seven men, aged 41-96 years) were treated laparoscopically. Four had undergone previous cholecystectomy. ERCP had been attempted in all patients, was unsuccessful in three patients, and had been interpreted as normal in two. Endoscopic stone extraction had been attempted in 14 patients. The mean follow-up period was 23 months, range 1-54 months. RESULTS: Ductal calculi were confirmed in 18 patients with successful and complete laparoscopic ductal clearance in 15 (83%), two of whom underwent an additional laparoscopic choledochoduodenostomy due to a large stone load and a grossly dilated common bile duct. Conversion to open surgery was required in three cases (17%). Ductal clearance at a single operation was achieved in all 18 patients. There were no postoperative deaths, but two patients developed postoperative complications (11% morbidity), one requiring laparotomy. The median postoperative hospital stay was five days, range 4-41 days. Recurrence of calculi was encountered in one patient. CONCLUSIONS: Laparoscopic ductal stone clearance after failed endoscopic stone extraction is successful in the majority of patients, and should be attempted prior to recourse to open surgery, provided the necessary laparoscopic biliary expertise is available.

Influence of direction of view, target-to-endoscope distance and manipulation angle on endoscopic knot tying.

INTRODUCTION: The aim of the study was to investigate the influence of (1) the direction of view of the endoscope, (2) the endoscope-to-task distance and (3) the manipulation angle between the instruments on intracorporeal endoscopic knotting. METHODS: Rigid endoscopes (0 degree, 30 degrees and 45 degrees) were introduced with the objective set at distances of 50, 75, 100, 125 and 150 mm from the task. Needle holders were inserted to make 30 degrees, 60 degrees and 90 degrees manipulation angles. The execution time and knot quality parameters of 2700 knots performed by ten surgeons were obtained. RESULTS: There was no significant difference in the execution time or parameters of knot quality with different endoscopes. The longest execution time (median 95 s, P < 0.0001) and the lowest performance quality score (20.61, P < 0.001) were observed at a distance of 50 mm when compared to other distances. A 60 degrees manipulation angle had a shorter execution time (median 71 s, P < 0.0001) and a higher performance quality score (26.84, P < 0.0001) than either 30 degrees or 90 degrees manipulation angles. CONCLUSION: The direction of view of the endoscope had no significant effect on intracorporeal knotting if the optical axis subtended the same angle with the task surface. The optimal ergonomic conditions include an endoscope-to-target distance of 75-150 mm and a manipulation angle of 60 degrees.