ABSTRACT
BACKGROUND: Photorefractive keratectomy with large diameter ablations using a uniform laser beam has produced central undercorrections, or "steep central islands" in patients, as seen with videokeratography. METHODS: Using a custom optical profilometer to measure corneal ablation profiles and a VISX excimer laser system, we measured the effect of ablation algorithms, diameter, depth, and dioptric correction on enucleated porcine eyes and living rabbit eyes. Our profilometer was verified using a 43.00 diopter (D) spherical surface and a 35.00 and 43.00 D bicurve test surface as a model for the ablated cornea. RESULTS: The profilometer measured the test surfaces to within 3 microns of predicted values. Photorefractive keratectomies showed over-ablation peripherally and under-ablation centrally which increased with ablation diameter and dioptric correction. Fixed diameter ablations 2 to 6 mm in diameter and 10 to 80 microns deep showed stromal ablation rates vary spatially but not with ablation depth. These spatially variant ablation profiles were used to re-engineer the ablation algorithm and to produce photorefractive keratectomies with improved sphericity. CONCLUSIONS: Steep central islands are caused by the spatial variance of tissue ablated with a uniform laser beam irradiance. This aberration can be corrected by modifying the laser ablation algorithm to correct for the spatial variance of stromal ablation.
Subject(s)
Cornea/pathology , Cornea/surgery , Image Processing, Computer-Assisted/methods , Photorefractive Keratectomy/methods , Algorithms , Animals , Image Processing, Computer-Assisted/instrumentation , Lasers, Excimer , Predictive Value of Tests , Rabbits , Refraction, Ocular , SwineABSTRACT
In this paper, we examine the 193 nm excimer laser's efficacy and safety in treating myopic astigmatism. The VISX Twenty/Twenty excimer laser uses aperture elements to effect astigmatic photorefractive keratectomy. In 70 patients with six months follow-up, the average postoperative sphere was -0.14 and the average postoperative cylinder was -0.54. Seventy-one percent of these patients had uncorrected visual acuity of 20/40 or better at six months. In 12 patients with one year follow-up, the average postoperative sphere was -0.05 and the average postoperative cylinder was -0.59. Eighty-three percent of these patients had uncorrected acuities of 20/40 or better; none had a clinically significant loss of best corrected acuity. This investigation demonstrates that the excimer laser can be used to treat myopic astigmatism successfully.