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Mater Sci Eng C Mater Biol Appl ; 33(7): 3786-94, 2013 Oct.
Article in English | MEDLINE | ID: mdl-23910278

ABSTRACT

This paper introduces a facile method to make highly stable and recyclable antimicrobial magnetic nanoparticles (NPs). Initially, magnetic iron oxide nanoparticles (IONPs) were coated with poly (vinyl pyrrolidone) conjugated catechol (PVP-CCDP). Afterward, silver nanoparticles (Ag(0)) were deposited onto PVP-CCDP coated IONPs using remain catechol. The prepared nanoparticles showed long term (~4 weeks) colloidal stability and redispersibility, respectively, against external magnetic field and over a broad range of pH (4-12). The NPs were characterized by UV-vis, SEM, XPS, and XRD measurements. TEM and DLS analyses showed that the mean particle size of PVP-CCDP coated IONPs/Ag(0) were about 72 nm. The recyclable magnetic NPs possessed a high antibacterial effect against the model microbes Staphylococcus aureus and Escherichia coli and could be separated easily using magnet following antibacterial test for repeated uses and maintained 100% antibacterial efficiency during three cycles. In MTT assay, the magnetic nanoparticles possessed no measureable cytotoxicity to live cells.


Subject(s)
Catechols/pharmacology , Ferric Compounds/chemistry , Magnetic Phenomena , Metal Nanoparticles/chemistry , Pyrrolidinones/chemistry , Recycling , Silver/pharmacology , Animals , Anti-Infective Agents/pharmacology , Catechols/chemistry , Cell Death/drug effects , Cell Survival/drug effects , Coated Materials, Biocompatible/pharmacology , Dogs , Escherichia coli/drug effects , Madin Darby Canine Kidney Cells , Metal Nanoparticles/ultrastructure , Microbial Sensitivity Tests , Particle Size , Photoelectron Spectroscopy , Spectrometry, X-Ray Emission , Spectrophotometry, Ultraviolet , Staphylococcus aureus/drug effects
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