ABSTRACT
Baseline density of intact lymphocyte beta2 adrenoreceptors (B max., 3H-DHA) was compared to dynamics of left ventricular hypertrophy (LVH) and frequency of essential hypertension (EH) complications within 7-9-year follow-up in 27 patients with EH stage II. No significant correlation was noted between B max and LVH changes. In a subgroup of 9 patients with initially very high B max overall number of complications reached 77.8% against 27.5%) (p<0.05) in control. These patients also developed acute myocardial infarctions more frequently (33.3% versus 0%, p<0.05). Such complications as strokes, coronary failure occurred with the same frequency. More extended trials are needed to infer on prognostic value of lymphocytic beta2-adrenoreceptor density.
Subject(s)
Hypertension/physiopathology , Lymphocytes/chemistry , Receptors, Adrenergic, beta-2/analysis , Adult , Centrifugation, Density Gradient , Follow-Up Studies , Humans , Hypertension/complications , Hypertrophy, Left Ventricular/physiopathology , Male , Middle Aged , Prognosis , Receptors, Adrenergic, beta-2/physiology , Time FactorsSubject(s)
Calcium Channel Blockers/pharmacology , Coronary Disease/physiopathology , Hemodynamics/drug effects , Nifedipine/pharmacology , Pyridines/pharmacology , Verapamil/pharmacology , Adult , Cardiac Volume/drug effects , Coronary Disease/drug therapy , Humans , Male , Middle Aged , Plethysmography, Impedance/methods , Vascular Resistance/drug effectsABSTRACT
In 10 patients with stress stenocardia pharmacodynamics of Isoptin was studied with the aid of identical physical loads on the treadmill repeated with an hour's interval for 5-6 hours. A clearcut antianginal effect was recorded which consisted in the reduction of ST segment depression and of the pain syndrome for 5 hours after administration of 3 tablets over 5 hours and for 6 hrs 20 min after administration of 5 tablets of both drugs. The degree of effect increased considerably after the dose of isoptin was enhanced and was not changed after the dose of corinfar was enhanced. Difference in the haemodynamic effect of the drugs was found in their effect on the cardiac rate. Corinfar increased the cardiac rate, isoptin decreased it.
Subject(s)
Angina Pectoris/drug therapy , Calcium Channel Blockers/pharmacology , Hemodynamics/drug effects , Nifedipine/pharmacology , Pyridines/pharmacology , Verapamil/pharmacology , Adult , Angina Pectoris/physiopathology , Blood Pressure/drug effects , Dose-Response Relationship, Drug , Electrocardiography , Heart Rate/drug effects , Humans , Male , Middle AgedABSTRACT
The effect of Korinfar (30 and 50 mg) and isoptin (120 and 200 mg) on exercise tolerance was studied in 11 patients with angina pectoris of effort using the double blind crossover method. Both doses of Korinfar and 120 mg of isoptin increased cardiac output by 70--80% and 200 mg of isoptin--by 136%. Korinfar had a pronounced growth hypotensive effect and induced tachycardia, which is an increased dose hindered growth of exercise tolerance. The negative chronotropic effect of isoptin increased its efficacy. As a result of calcium antagonists action a stable threshold double product was established, and its was higher, than the control one.
