ABSTRACT
The case was a sixty-four-year-old female with a history of fibrous tumor in the right supraclavicular and neck region thirty years ago. A fibrous tumor developed in the right pleural cavity and was surgically resected. Since local recurrence occurred, the chest wall was partially resected including the tumor followed by reconstruction with a composite graft. This graft was made of hydroxyapatite filler wrapped with two sheets of Dacron fabric. A diagnosis of fibromatosis was made according to the study of the resected specimen, which showed unclear borders, homogenisity, poor evidence of nuclear atypia and mitosis in histological examination as well as negative finding of CD 34 in immunohistochemical examination.
Subject(s)
Fibroma/surgery , Plastic Surgery Procedures/methods , Pleural Neoplasms/surgery , Thoracic Surgical Procedures , Female , Humans , Middle Aged , Polyethylene Terephthalates , RecurrenceABSTRACT
A 54-year-old female was admitted to our hospital for gingival bleeding and was diagnosed as acute promyelocytic leukemia (APL). She received induction therapy according to the AML92 protocol of the Japan Adult Leukemia Study Group (JALSG) with all-trans retinoic acid (ATRA) plus chemotherapeutic agents. She achieved complete remission, but one year later had a relapse in her external auditory canal without leukemic cell in the bone marrow. Extramedullary disease is rare in APL. This case suggests the importance of careful observation for extramedullary relapse in patients who are treated with ATRA.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Ear Canal , Leukemia, Promyelocytic, Acute/pathology , Agranulocytosis/chemically induced , Agranulocytosis/drug therapy , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Biomarkers, Tumor/analysis , Combined Modality Therapy , Cytarabine/administration & dosage , Cytarabine/analogs & derivatives , Daunorubicin/administration & dosage , Female , Granulocyte Colony-Stimulating Factor/therapeutic use , Humans , Idarubicin/administration & dosage , Leukemia, Promyelocytic, Acute/drug therapy , Leukemia, Promyelocytic, Acute/radiotherapy , Mercaptopurine/administration & dosage , Middle Aged , Mitoxantrone/administration & dosage , Neoplasm Proteins/analysis , Oncogene Proteins, Fusion/analysis , Radiotherapy , Recurrence , Remission Induction , Salvage Therapy , Tretinoin/administration & dosage , Vindesine/administration & dosageABSTRACT
We prepared new 7-hydroxyguanine derivatives, 7-hydroxyguanosine 5'-monophosphate and N2-tetrahydropyranyl-7-hydroxyguanine, and compared biological activities of 7-hydroxyguanine derivatives including nucleosides acquired previously. 7-Hydroxyguanine and its nucleotide inhibited the focus formation of Rous sarcoma virus. Antitumor activities of these derivatives against mouse leukemia L1210 were not so different from one another. Anti-proliferative activities of the derivatives on various human cell lines were significantly different from one another.
