ABSTRACT
The free radical scavenger edaravone is able to stimulate prostacyclin release and inhibit the lipoxygenase pathway in the arachidonic acid cascade. The effect of edaravone administration on myocardial damage in rabbit hearts subjected to ischaemia-reperfusion was examined at different times relative to reperfusion. All rabbits underwent sustained coronary artery occlusion for 30 min followed by 3 h of reperfusion. Rabbits were divided into the following groups: control; early (3 mg/kg edaravone IV 10 min before reperfusion); immediate (3 mg/kg edaravone IV immediately after the start of reperfusion); and late (3, 6 or 10 mg/kg edaravone IV 5 min after the start of reperfusion). Single bolus administration of edaravone 10 min before reperfusion or immediately upon initiation of reperfusion appears to be associated with reductions in infarction size and the percentage of apoptotic cells, but treatment with edaravone 5 min after initiation of reperfusion does not appear to have this protective effect.
Subject(s)
Antipyrine/analogs & derivatives , Cardiotonic Agents/administration & dosage , Myocardial Reperfusion Injury/prevention & control , Animals , Antipyrine/administration & dosage , Antipyrine/pharmacology , Apoptosis/drug effects , Cardiotonic Agents/pharmacology , DNA Fragmentation/drug effects , Drug Evaluation, Preclinical , Edaravone , Free Radical Scavengers/therapeutic use , Myocardial Infarction/drug therapy , Myocardial Infarction/prevention & control , Myocardial Reperfusion Injury/drug therapy , Myocardial Reperfusion Injury/pathology , Rabbits , Time FactorsABSTRACT
A 55-year-old man was admitted to our hospital complaining of dyspnea and chest pain. Transthoracic echocardiography showed dilation of the right ventricle. Chest computed tomography with contrast medium showed multiple emboli in the pulmonary arteries. Venography of the lower extremities showed multiple thrombi in the right popliteal vein and the presence of left-sided vena cava. This unusual case of left-sided vena cava was complicated by deep vein thrombosis due to hemostasis. A Greenfield filter was placed in the vena cava proximal to the right renal vein in a right internal jugular vein approach.
Subject(s)
Pulmonary Embolism/complications , Vena Cava Filters , Vena Cava, Inferior/abnormalities , Humans , Male , Middle Aged , Renal Veins , Venous Thrombosis/complicationsABSTRACT
The rheological characteristics of a model matrix, consisting of Bacto-agar, were correlated with the ability of the matrix to permit cellular penetration, using a rheolometer and the agar bullet method. The most important rheologic characteristic that affected cellular mobility was found to be the viscosity rate. A viscosity rate under 1,000 X 10(4) dyne sec/cm2 was needed to permit cellular mobility.
Subject(s)
Agar , Leukocytes/physiology , Rheology , Adhesiveness , Animals , Cell Movement , Elasticity , Hardness , In Vitro Techniques , Models, Biological , Rabbits , ViscosityABSTRACT
Morphological changes of blood vessel walls including various kinds of capillaries have been induced by administration of soluble immune complexes. After repeated administrations, those experimental animals who survived the phase of initial anaphylactic shock developed osteomyelitis. In this paper, the formative processes of osteomyelitis will be discussed in relation to Aschoff's definition of inflammation. We will emphasize the importance of the capillarization of the sinusoidal endothelia for the formation of osteomyelitis.
