[The influence of nooclerin on the structure of sleep disturbances in children with tension headaches]. / Vliianie nooklerina na strukturu narushenii sna u detei s golovnymi boliami napriazheniia.

AIM: To study the effects of nooclerin (deanol aceglumate) on the structure of sleep disturbances in children with tension-type headache (TTH). MATERIAL AND METHODS: A blind randomized placebo-controlled study of the efficacy of nooclerin (deanol aceglumate), prescribed for 2 months to prevent TTH, was carried out. The study included 60 patients (30 boys and 30 girls), aged 9-16 years, with TTH. Patients were randomized into the nooclerin group (n=30) and the placebo group (n=30). Sleep disturbances were assessed before and after treatment with the Sleep Disturbance Scale for Children (SDSC). RESULTS: There was a significant positive dynamics (reduced total score on SDSC (p<0.001) and a significant decrease in the scores on scales 'Disorders of initiating and maintaining sleep', 'Disorders of excessive somnolence' (p<0.001), 'Sleep wake transition disorders' (p<0.01)) in the nooclerin group. No significant positive changes were detected in the placebo group. CONCLUSION: An anxiolytic action of nooclerin was confirmed. Further studies of the drug in child neurology and psychiatry using larger groups of patients are needed.

[Tension type headaches in children and adolescents: co-morbidity with emotional and behavioral disorders]. / Golovnye boli napriazheniia u detei i podrostkov: komorbidnost' s émotsional'nymi i povedencheskimi rasstroistvami.

AIM: To assess the incidence of emotional and behavioral disorders in children and adolescents with frequent episodic or chronic tension type headaches (TTH). MATERIAL AND METHODS: One hundred and fifty patients with TTH (75 boys and 75 girls), aged 8-16 years, were included in the study. The severity of emotional and behavioral problems was analyzed in comparison with their healthy peers by means of parents' interviewing with the 'Strengths and Difficulties Questionnaire' (SDQ). RESULTS: Total difficulties scores measured by SDQ were significantly higher in boys (16.2±0.7) and girls (14.3±0.7) with TTH compared with their peers (7.9±0.4 and 7.7±0.4, respectively, p<0.001). Patients with TTH had significantly more prominent manifestations than their peers (p<0.001) on the four SDQ scales, including Hyperactivity and Inattention, Conduct problems, Emotional symptoms, Peer problems. Clinical examination revealed in many pediatric patients with TTH the following disorders: attention deficit hyperactivity disorder (45.3% boys and 13.3% girls), oppositional defiant disorder (26.7% boys, 18.7% girls), with co-occurrence of both disorders in some patients (17.3% boys, 10.7% girls). Moreover, most patients with TTH had anxiety disorders (68.0% boys, 77.3% girls). CONCLUSION: Clinical features and duration of TTH may be dependent on the severity of co-morbid emotional and behavioral disorders. This should be taken into account for individualized indication of drug therapy and non-pharmacological treatment approaches in pediatric TTH.

[Possibilities of preventive treatment of tension-type headache in children and adolescents]. / Vozmozhnosti profilakticheskoi terapii pri golovnoi boli napryazheniya u detei i podrostkov.

AIM: To study clinical characteristics mechanisms and pathogenesis of the tension-type headache (TTH) in children and adolescents treated with nooclerin. MATERIAL AND METHODS: The blind randomized placebo-controlled study of the efficacy of nooclerin (deanol aceglumate) indicated during 2 months as a preventive treatment of TTH was performed. Forty patients (15 male and 25 female), aged 9-16 years, were randomized into two equal groups to receive either nooclerin or placebo. RESULTS AND CONCLUSION: Nooclerin significantly reduced the frequency, duration and intensity of TTH. The treatment resulted in positive dynamics in daily activities, regression of fatigue symptoms and normalization of the sleep-wake cycle.