1.
Ukr Biokhim Zh (1999)
; 73(5): 49-54, 2001.
Article
in Russian
| MEDLINE
| ID: mdl-12035504
ABSTRACT
The hydrophilic head of melittin (peptide from bee venom) has the amino acid sequence which is very close to the amino acid sequence of C1q-binding site of the IgG molecule. It was shown, that melittin caused the multiple growth of the interaction of C1q with IgG monoclonal antibody. We assume, that the appearance of melittin in blood causes the spontaneous antigen-independent aggregation of IgG and C1q with the following triggering of the classical pathway of the complement cascade and origin of C3a and C5a components. This can be one of the mechanisms of anaphylaxis as an answer to bee venom.
Subject(s)
Anaphylaxis/immunology , Bee Venoms/toxicity , Complement C1q/metabolism , Immunoglobulin G/metabolism , Melitten/toxicity , Animals , Antibodies, Monoclonal/immunology , Humans , Immunoglobulin G/immunology , Mice
2.
Fiziol Cheloveka
; 20(4): 168-70, 1994.
Article
in Russian
| MEDLINE
| ID: mdl-7813841