ABSTRACT
The aim of the study was to evaluate the effects of clonidine on the cardiovascular and respiratory systems after cardiac surgery. Ninety-six patients who had undergone scheduled myocardial revascularization were examined. According to the type of used anesthesia, the examinees were divided into 2 groups: 1) 60 patients who received standard anesthesia (a control group) and 2) 36 patients in whom the anesthesia was supplemented by clonidine. In Group 2, the total dose of the narcotic analgesic phentanyl was 14.15 +/- 6 microg/kg while in Group 1, the dose of opiod was 18.13 +/- 4.75 microg/kg (p < 0.05). Statistically significant minimum doses of catecholamines were more frequently used in Group 2 (27% versus 15% in the control group) (p < 0.05). The duration of artificial ventilation was 9.6 +/- 7.5 and 9.2 +/- 5.5 hours in Groups 1 and 2, respectively (p > 0.05). Positive fluid balance within the first 24 postoperative hours was 2324 +/- 1450 and 1587 +/- 1019 ml in Groups 1 and 2, respectively (p > 0.001).
Subject(s)
Analgesics/administration & dosage , Cardiovascular System/drug effects , Clonidine/administration & dosage , Heart Diseases/surgery , Respiratory System/drug effects , Aged , Analgesics/adverse effects , Anesthesia/adverse effects , Clonidine/adverse effects , Female , Humans , Male , Middle Aged , Myocardial Revascularization , Postoperative PeriodABSTRACT
The article deals with the description and analysis of the first two operations undertaken for the development of the method and the first clinical use of extended myoventriculoplasty with programmed cardiosynchronized electroneurostimulation. The authors elaborated the items of stage-by-stage training of the skeletal muscle for its adaptation to work in a regimen of the contracting heart, and the techniques of myoventriculoplasty in patients with a complicated form of ischemic heart disease and dilatation cardiomyopathy. Apart from that, the authors approved for the first time in the clinic an original Soviet-made programmed cardiosynchronized electroneurostimulator intended for implantation. The immediate postoperative results were satisfactory.
