[Automated method for separate measurement of coproporphyrins and uroporphyrins in the urine]. / Avtomatizirovannyi metod razdel'nogo izmereniia kopro- i uroporfirinov v moche.

The authors suggest a new improved automated method for separate measurements of urinary porphyrins (coproporphyrins and uroporphyrins) in native urine with computer processing of spectral data. The method of dividing the total spectrum of porphyrin fluorescence takes account of background non-porphyrin admixtures in the urine and corrects the data on the basis of regression analysis. The data of this method were compared to those of other widely used methods and were found to be in good correlation; the advantages of the automated method are discussed.

[Assessment of the possibility of using the photodynamic effect in rheumatology]. / Otsenka vozmozhnosti ispol'zovaniia fotodinamicheskogo éffekta v revmatologii.

Results of the analysis of a number of parameters which determine the efficiency of using the photodynamic action for treating rheumatoid arthritis are reported. The investigations are based on determining the character of sensitizer stabilization in the joint tissue and evaluating its stability. As the sensitizer chlorin e6 was chosen. We have established the fact of contrast accumulation of chlorin e6 in the synovial membrane and cartilage, developed the system of intrajoint introduction of the pigment, studied the kinetics of sensitizer destruction under irradiation.

[The use of porphyrins for assessing the effect of low doses of ionizing radiation on the human body]. / Ispol'zovanie porfirinov dlia otsenki vliianiia malykh doz ioniziruiushchego izlucheniia na organizm cheloveka.

Data on porphyrin metabolism disturbances under the action of ionizing radiation on the human body are presented. The studies are based on estimating the quantitative content of coproporphyrin in the diurnal urine diuresis of persons irradiated as a result of the Chernobyl accident. The results of examining the population of a number of the zones of close control in Mogilev and Gomel Provinces are considered. Unlike the presumably healthy subjects, many people of this group show a significant decrease of porphyrin excretion with urine. The discovered sensitivity to the action of radiation is individual. A preliminary estimation of the porphyrin test depending on the degree of morphological changes in the gastric mucosa was made during an all-round clinical examination of the irradiated subjects.

[Determination of coproporphyrin in urine]. / Opredelenie koproporfirina v moche.

Methods for urinary coproporphyrin measurements are analyzed. Data obtained by two methods, spectrophotometry and fluorescent method, are presented, the advantages and shortcomings of both are discussed. The authors recommend the fluorescent technique as a universal rapid method for wide medical practice. The problem of the units of coproporphyrin measurement is also discussed. The authors suggest replacing measurements per g of creatinine or daily portion by estimation of the coproporphyrin index in the morning portion of the urine. Study of the effects of various factors (climatic conditions, nutrition, patient's age and sex) on normal coproporphyrin excretion from the body has demonstrated that these factors do not noticeably influence porphyrin metabolism; for normal subjects the coproporphyrin index varies from 30 to 110 micrograms/day.

[Quantitative and qualitative composition of porphyrins in erythrocytes of cancer patients]. / Kolichestvennyi i kachestvennyi sostav porfirinov v éritrotsitakh onkologicheskikh bol'nykh.

Content of copro- and protoporphyrins was studied in erythrocytes of women with tumor of genitals. Distinct increase in content of these porphyrins, especially of protoporphyrin, was detected in erythrocytes of the patients with malignant tumors as compared with the patterns of healthy persons.