ABSTRACT
The diagnostic value of enzyme immunoassay systems manufactured by different companies was comparatively studied to detect specific IgM antibodies to measles virus. The assay systems were shown to have a high sensitivity. The specificity was higher in the assay systems designed on the capture principle, a type of solid-phase enzyme immunoassay.
Subject(s)
Antibodies, Viral/blood , Immunoenzyme Techniques , Immunoglobulin M/blood , Measles virus/immunology , Measles/diagnosis , Reagent Kits, Diagnostic , Antibodies, Viral/immunology , Antibody Specificity , Humans , Immunoglobulin M/immunology , Measles/blood , Sensitivity and SpecificityABSTRACT
The work was aimed at the evaluation of the antigenic activity and reactogenicity of antirubella vaccine, manufactured by the Serum Institute of India, on the basis of the active observation of 373 children. Vaccinal reactions were registered in 8.8% of the vaccinees. Seroconversion after the injection of the vaccine was 100%. The results of the epidemiological trial demonstrated that the Indian antirubella vaccine was faintly reactogenic and had high antigenic activity.
Subject(s)
Rubella Vaccine/administration & dosage , Rubella virus/immunology , Rubella/prevention & control , Vaccination , Adolescent , Antibodies, Viral/blood , Antibody Specificity , Child , Child, Preschool , Fever/chemically induced , Humans , Infant , Rubella/blood , Rubella Vaccine/adverse effects , RussiaABSTRACT
A total of 3422 adolescent girls and women of a reproductive age were vaccinated against rubella with French vaccine. Antigenic activity and reactogenicity of the vaccine were assessed in 97 girls, 100% seroconversion and weak reactogenicity was observed in seronegative vaccinees.
Subject(s)
Rubella Vaccine/immunology , Rubella/prevention & control , Adolescent , Adult , Antibodies, Viral/biosynthesis , Antigens, Viral/immunology , Child , Female , Humans , Rubella Vaccine/adverse effectsABSTRACT
The results of field clinical trials of Russian and American yeast vaccines against hepatitis B are presented. The study revealed that both vaccines were faintly reactogenic, safe and exhibited high immunological activity. After the full course of immunization following the schedule 0-1-2 months 92.5% and 97.5% of patients receiving, respectively. Russian vaccine "Combiotech" and American vaccine "H-B-Vax II" were found to have specific antibodies. The maximum effect was registered when the vaccines were introduced according to the schedule 0-1-6 months. Seroconversions were observed in 97.5% and 100% of the vaccinees receiving the Russian and American vaccines respectively, in the latter case the highest antibody level being observed. The use of the vaccines within the prophylactic immunization schedule showed that antibodies to hepatitis B appeared in immunized children in 93-100% of cases. Seroconversion indices and the levels of antibodies to diphtheria, tetanus, poliomyelitis and measles were statistically significant and were the same in children receiving only the vaccines according to the immunization schedule and in children immunized, in addition to these vaccines, against hepatitis B.
Subject(s)
Hepatitis B Vaccines/administration & dosage , Hepatitis B/prevention & control , Immunization Schedule , Vaccines, Synthetic/administration & dosage , Adolescent , Adult , Antibody Specificity , Female , Hepatitis B Antibodies/blood , Hepatitis B Vaccines/adverse effects , Hepatitis B Vaccines/immunology , Humans , Infant , Infant, Newborn , Male , Time Factors , Vaccines, Synthetic/adverse effects , Vaccines, Synthetic/immunologyABSTRACT
Live measles vaccines prepared from different strains in France, Japan, and Russia were compared at the L. A. Tarasevich State Institute for Standardization and Control of Viral Preparations. Clinical reactions to the tested vaccines were studied in 181 children seronegative before vaccination. Vaccinal reactions to French, Japanese, and Russian were observed in 24.2, 26.5, and 5.9% vaccinees, respectively. The French and Russian vaccines virtually did not differ by the level of seroconversion (96 and 98.1%, respectively). For the Japanese vaccine the level of sero-conversion was lower: 91.6%. The mean titers of antibodies in vaccinees immunized with the French, Japanese, and Russian vaccines were, respectively, 7.36 +/- 0.91, 2.07 +/- 0.42, and 4.40 +/- 0.42 IU.
Subject(s)
Measles Vaccine/standards , Antibodies, Viral/biosynthesis , Antibodies, Viral/blood , Child, Preschool , France , Humans , Japan , Measles Vaccine/adverse effects , Measles Vaccine/immunology , RussiaABSTRACT
The reactogenicity and antigenic activity of live measles vaccine prepared from strain Leningrad-16 were assessed for 4 territories, two of which were exposed to radiation contamination as a result of the Chernobyl accident. The study was carried out at the L. A. Tarasevich State Institute for Standardization and Control of Viral Preparations. The vaccine was weakly reactogenic in all the regions; no grave or uncommon reactions to its administration were observed. Serologic studies revealed a high antigenic activity of the vaccine. The level of seroconversion was estimated as 98.5%. The study failed to detect any appreciable effect of radiation contamination on the tolerance to vaccine or level of immune response.
